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LifeLines Cohort Study & Biobank [LifeLines] Download as PDF

GENERAL INFORMATION

Name LifeLines Cohort Study & Biobank
Acronym LifeLines
Last update 09/11/2013

Affiliation

Principal investigator

Ronald P. Stolk (Chief Scientific Officer)
University Medical Center Groningen

Contacts

Lifelines Research Office
Groningen 9713 BZ
Email: LLScience@umcg.nlMail
Ymke van der Geld (Manager Lifelines Research Office)
Lifelines Research Office
Groningen 9713 BZ
Email: LLScience@umcg.nlMail
Ronald P. Stolk (Chief Scientific Officer)
University Medical Center Groningen
Groningen 9700 RB
Phone: +31-50-361-1879
Email: r.p.stolk@umcg.nlMail

Website

Funding agency

Percentage Category
The Netherlands Organization for Scientific Research (NWO) 5% Public Research Funding
University Med Center Groningen/ University of Groningen 15% --
Dutch Kidney Foundation -- Charity
Governement, 3 northern provinces of The Netherlands 80% Governmental funding
Dutch Diabetes Research Foundation -- Charity

OBJECTIVES

Overall aim of the study:
Unravel the interaction between genetic and environmental factors in the development of multifactorial diseases, their concurrent development in individuals and their complications as a complex trait.
Primary objectives:
Which are the disease overriding risk factors which predict the development of a multifactorial disease during lifetime? How are these universal risk factors modified, or what determines the effect of a universal risk factor in an individual? Specific research questions will focus on risk factors and modifiers (genetic, environmental and combined or complex factors) for single and multiple diseases. In addition to co-morbidity, LifeLines focuses on co-determinants. The primary endpoints include measures of ageing, metabolic and endocrine diseases, cardiology, renal diseases, pulmonary and musculoskeletal diseases, and psychopathology.
Secondary objectives:
Secondary aims include the assessment of the prevalence and incidence of multifactorial diseases and their risk factors in individuals as well as in families. The burden of disease for the society will be quantified in terms of care needed, and total costs of care.

Research Focus

  • No Broad approach with no specific target of interest (study built as an infrastructure for a broad range of unspecified scientific activities/questions).
  • Yes Target specific questions of interest (predefined scientific targets like, cardiovascular diseases, social environment, specific health trajectories etc.)
Topics ICD-10 classificationExternal
Yes Endocrine, nutritional and metabolic diseases (E00-E90)
Yes Mental and behavioural disorders (F00-F99)
Yes Diseases of the circulatory system (I00-I99)
Yes Diseases of the respiratory system (J00-J99)
Yes Diseases of the digestive system (K00-K93)
Yes Diseases of the skin and subcutaneous tissue (L00-L99)
Yes Diseases of the musculoskeletal system and connective tissue (M00-M99)
Yes Diseases of the genitourinary system (N00-N99)

Supplementary informations

General focus on frequently occurring multifactorial disorders and multidisease factors.

METHODS

Legend Yes No Unknown

General design

Study design Cohort
Type of participants Individuals, Families
Target or final number of participants 165000
  The project will include 165.000 participants: 45.000 probands,30.000 partners, 55.000 parents-(in law) and 35.000 children.
    Target or final number of families 45000
Target or final number of DNA 165000

Participant selection / Characteristics of the population

Selection criteria

Yes Age Minimun: 25 years    Maximun: 50 years
Yes Country of residence Netherlands (Three Northern provinces: Groningen, Friesland and Drenthe)
Yes Health status / clinical criteria (Severe psychiatric or physical illness are excluded)
Yes Other criteria Being able to speak Dutch.

Supplementary informations

The study population consists of a representative sample of the population of the northern provinces of the Netherlands, covering three generations. The LifeLines project will include 165.000 participants: anticipated to consist of approximately 45.000 probands, 30.000 partners ( all between 25 and 50 yrs), 55.000 parents-(in law) (> 55 yrs) and 35.000 children (< 25 yrs) (other participants: no age criterium). Based on the age of the participant, he or she is included in the children’s cohort (0-18 years), the adult cohort (18-65 years) or the elderly cohort (>65 years). The participants are followed for at least 30 years and are invited every 5 years for a visit to the LifeLines research facility. In the years in between the participants receive follow-up questionnaires.

Data Sources

  Cross-sectional Longitudinal follow-up
Yes Questionnaires to participants/respondents Yes Yes
Yes Direct physical measures Yes Yes
Yes Biological samples Yes Yes

Sample management

Biological samples

Yes Blood No Buccal cells
No Cord blood No Tissues
No Saliva Yes Urine

Genome-Wide Association (GWA) analyses

  • Yes Already or currently generating GWA data. Approximate number of participants : Yes, we have already GWA data on 13000 participants.
  • Yes Plan to proceed to GWA analyses later

GOVERNANCE

Legend Yes No

Allow access to data or samples to external researchers

Academia Industry
Yes Data (questionnaire-derived, measured…) Yes Yes
Yes Biological samples Yes Yes

STATUS

Current status

Phase Start End
Preparation phase/Pilot 2004 2006
Baseline recruitment / initial data collection 2006 2013
Follow-up of participants 2011 2036
Study ended   2036
Current number of participants recruited 140365 in date of 06/14/2013
Current number of collected DNA samples 140365 in date of 06/14/2013

PUBLICATIONS AND RELEVANT DOCUMENTATION

Marker paper describing the study

Stolk RP, Rosmalen JG, Postma DS, de Boer RA, Navis G, Slaets JP, Ormel J, Wolffenbuttel BHR. Universal risk factors for multifactorial diseases: LifeLines: a three-generation population-based study. Eur J Epidemiol 2008; 23(1): 67-74. PUBMED 18075776External

COMMENT

Funding for baseline measurement and partly for follow-up has been obtained


This Catalogue was archived on: 2013-12-09. Information included in this Catalogue is for informational purposes only.

General Information

Name LifeLines Questionnaire
Last update 08/13/2012
Phase Baseline

Contacts

Lifelines Research Office
University Medical Center Groningen
Groningen 9713 BZ
Email: LLScience@umcg.nlMail
Ronald P. Stolk (Chief Scientific Officer)
Groningen 9700 RB
Phone: +31-50-361-1879
Email: r.p.stolk@umcg.nlMail

Documents

Available Format

NOTICE: HTML document format may differ slightly from the actual questionnaire. Please refer to the original PDF document for exact reproduction.

General Information

Name LifeLines Questionnaire
Number of Question Blocks 62

Questionnaire and Question Block List

Click on the View block to see the block of questions related to a domain or a group of domains.
Block 2 View block
  • Sociodemographic Characteristics / Gender
Block 3 View block
  • Sociodemographic Characteristics / Age/Birth Date / Subject age / birth date
Block 4 View block
  • Sociodemographic Characteristics / Birth location / Subject's birth location
Block 5 View block
  • Sociodemographic Characteristics / Birth location / Subject's family's birth location
Block 6 View block
  • Sociodemographic Characteristics / Household Status / Subjet Household Status
Block 7 View block
  • Social Environment / Familial and social environment
  • Sociodemographic Characteristics / Residence / Residential History
Block 8 View block
  • Sociodemographic Characteristics / Household Status / Structure of the Household
Block 9 View block
  • Body Functions / Handedness / laterality / Handedness
Block 10 View block
  • Sociodemographic Characteristics / Age/Birth Date / Subject's Relatives Age / Birth Date
Block 11 View block
  • Socioeconomic Characteristics / Working status / Subject Working status/history
Block 12 View block
  • Socioeconomic Characteristics / Income
Block 13 View block
  • Socioeconomic Characteristics / Working status / Subject Working status/history
Block 14 View block
  • Socioeconomic Characteristics / Education level / Subject education level
Block 15 View block
  • Socioeconomic Characteristics / Working status / Subject Working status/history
Block 16 View block
  • Social Environment / Familial and social environment
Block 17 View block
  • Life Habits/Behaviours / Sleep Behaviours
Block 18 View block
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving the circulatory and respiratory systems
  • Health Information / Individual Disease history / Diseases of the respiratory system
Block 19 View block
  • Health Information / Individual Disease history / Diseases of the respiratory system
Block 20 View block
  • Health Information / Individual Disease history / Factors influencing health status and contact with health services
  • Health Information / Individual Disease history / Injury, poisoning and certain other consequences of external causes
Block 21 View block
  • Health Information / Individual Disease history / Neoplasms
Block 22 View block
  • Health Information / Individual Disease history / Endocrine, nutritional and metabolic diseases
  • Health Information / Medication Intake (ATC/DDD) / Alimentary tract and metabolism (A)
Block 23 View block
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Cardiovascular System
  • Health Information / Medication Intake (ATC/DDD) / Cardiovascular system (C)
  • Health Information / Individual Disease history / Diseases of the circulatory system
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving the circulatory and respiratory systems
Block 24 View block
  • Health Information / Individual Disease history / Endocrine, nutritional and metabolic diseases
Block 25 View block
  • Health Information / Individual Disease history / Diseases of the nervous system
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / General symptoms and signs
  • Health Information / Individual Disease history / Diseases of the circulatory system
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving speech and voice
Block 26 View block
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Musculoskeletal System
  • Health Information / Individual Disease history / Diseases of the musculoskeletal system and connective tissue
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / General symptoms and signs
Block 27 View block
  • Health Information / Individual Disease history / Diseases of the genitourinary system
Block 28 View block
  • Health Information / Medical Health Intervention (C239) / Diagnostic Interventions / Diagnostic Interventions on the Genitourinary System
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Abnormal findings on examination of urine, without diagnosis
Block 29 View block
  • Health Information / Individual Disease history / Diseases of the genitourinary system
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Genitourinary System
Block 30 View block
  • Health Information / Individual Disease history / Endocrine, nutritional and metabolic diseases
Block 31 View block
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / General symptoms and signs
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Eyes and Ocular Adnexa
Block 32 View block
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / General symptoms and signs
  • Health Information / Medical Health Intervention (C239) / Cognitive, Psychosocial and Sensory Therapeutic Interventions / Therapeutic Interventions for Hearing
Block 33 View block
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Orocraniofacial Unit
  • Health Information / Individual Disease history / Diseases of the digestive system
Block 34 View block
  • Health Information / Individual Disease history / Diseases of the eye and adnexa
  • Health Information / Individual Disease history / Diseases of the digestive system
  • Health Information / Individual Disease history / Diseases of the musculoskeletal system and connective tissue
  • Health Information / Individual Disease history
  • Health Information / Individual Disease history / Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • Health Information / Individual Disease history / Diseases of the nervous system
  • Health Information / Individual Disease history / Diseases of the genitourinary system
  • Health Information / Individual Disease history / Diseases of the skin and subcutaneous tissue
  • Health Information / Individual Disease history / Mental and behavioural disorders
  • Health Information / Individual Disease history / Diseases of the circulatory system
  • Health Information / Individual Disease history / Diseases of the respiratory system
Block 36 View block
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Genitourinary System
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Musculoskeletal System
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Digestive and Hepatobiliary Tract
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Respiratory System
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Cardiovascular System
Block 37 View block
  • Health Information / Medication Intake (ATC/DDD)
  • Health Information / Medication Intake (ATC/DDD) / Blood and blood forming organs (B)
  • Health Information / Medication Intake (ATC/DDD) / Alimentary tract and metabolism (A)
  • Health Information / Medication Intake (ATC/DDD) / Various
  • Health Information / Medication Intake (ATC/DDD) / Nervous system (N)
  • Health Information / Medication Intake (ATC/DDD) / Musculo-skeletal system (M)
  • Health Information / Medication Intake (ATC/DDD) / Cardiovascular system (C)
Block 38 View block
  • Health Information / Medical Health Intervention (C239) / Cognitive, Psychosocial and Sensory Therapeutic Interventions / Therapeutic Interventions for Communication
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Musculoskeletal System
  • Health Information / Medical Health Intervention (C239) / Other Healthcare Interventions
  • Health Information / Medical Health Intervention (C239) / Cognitive, Psychosocial and Sensory Therapeutic Interventions / Therapeutic Interventions on the Psyche (mental health)
  • Health Information / Medical Health Intervention (C239) / Cognitive, Psychosocial and Sensory Therapeutic Interventions / Therapeutic Interventions for Voice
Block 39 View block
  • Health Information / Perception of health/quality of life
Block 40 View block
  • Life Habits/Behaviours / Physical activity / Perception of physical health
Block 41 View block
  • Health Information / Perception of health/quality of life
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving cognition, perception, emotional state and behaviour
  • Social Environment / Familial and social environment
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving the nervous and musculoskeletal systems
Block 42 View block
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving the nervous and musculoskeletal systems
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving the digestive system and abdomen
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / General symptoms and signs
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving the circulatory and respiratory systems
Block 43 View block
  • Health Information / Reproductive history / Parity/Gravidity
  • Health Information / Medical Health Intervention (C239) / Obstetrical and Fetal Interventions / Termination of Pregnancy
  • Health Information / Reproductive history / Number of children
Block 44 View block
  • Health Information / Women's health / Menstruation
Block 45 View block
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Genitourinary System
Block 46 View block
  • Health Information / Medication Intake (ATC/DDD) / Genito urinary system and sex hormones (G)
Block 47 View block
  • Health Information / Medication Intake (ATC/DDD) / Genito urinary system and sex hormones (G)
Block 50 View block
  • Sociodemographic Characteristics / Gender
Block 51 View block
  • Sociodemographic Characteristics / Age/Birth Date / Subject age / birth date
Block 52 View block
  • Life Habits/Behaviours / Weight related behaviours
  • Life Habits/Behaviours / Nutrition / Nutritional Behaviours and Perception of Nutritional Habits
  • Body structures / Anthropometric structures / Anthropometric measures / Weight
Block 53 View block
  • Health Information / Participants Early Life Conditions / Participant's Birth weight
Block 54 View block
  • Health Information / Participants Early Life Conditions / Participant's Birth height
Block 55 View block
  • Health Information / Participants Early Life Conditions / Participant's Pregnancy duration
Block 56 View block
  • Life Habits/Behaviours / Early life/childhood / History of Being Breastfed
Block 57 View block
  • Health Information / Participants Early Life Conditions / Participant's Newborn/childhood health
  • Health Information / Individual Disease history / Congenital malformations, deformations and chromosomal abnormalities
Block 58 View block
  • Life Habits/Behaviours / Tobacco use
Block 59 View block
  • Physical Environment / Environmental exposures / Chemical environmental exposures / Passive Smoke Exposure
  • Physical Environment / Occupational Exposures / Chemical Occupational Exposures / Passive Smoke Exposure
Block 60 View block
  • Physical Environment / Early life and in utero exposures / Chemical Exposures / Passive Smoke Exposure
Block 61 View block
  • Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency
Block 62 View block
  • Social Environment / Familial and social environment
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving cognition, perception, emotional state and behaviour
  • Social Environment / Working Social Environment
Block 63 View block
  • Physical Environment / Environmental exposures / Biological environmental exposures
  • Physical Environment / Environmental exposures / Chemical environmental exposures
Block 64 View block
  • Social Environment / Working Social Environment
  • Social Environment / Familial and social environment
Block 67 View block
  • Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency
Block 68 View block
  • Physical Environment / Early life and in utero exposures / Biological Exposures
  • Physical Environment / Early life and in utero exposures / Chemical Exposures

This Catalogue was archived on: 2013-12-09. Information included in this Catalogue is for informational purposes only.

GENERAL INFORMATION

Study name LifeLines Cohort Study & Biobank [LifeLines]
Last update 08/13/2012
Collected at phase Baseline

Contacts

Ronald P. Stolk (Chief Scientific Officer)
University Medical Centre Groningen
Groningen 9700 RB
Phone: +31-50-361-1879
Email: r.p.stolk@umcg.nlMail

Physical and cognitive measures collected

Legend Yes No

BODY STRUCTURES

ANTHROPOMETRIC STRUCTURES

Anthropometric measures

Yes Weight

Yes Height

Yes Standing height

Yes Body circumferences

Yes Waist circumference

Yes Hip circumference

OTHER BODY STRUCTURES

Yes Other body structure measures (Measurement of skin autofluorescence with a non-invasive AGE-reader (Advanced Glycation Endproducts))

BODY FUNCTIONS

MENTAL FUNCTIONS

Global mental functions

Yes Cognitive functions (Ruffs Figural Fluency Test (RFFT))

Yes Other global mental functions (e.g. IQ) (MMSE (minimal mental state examination) for participants of 65 years and older)

Specific mental functions

Yes Other specific mental functions (Neuropsychiatric interview in which a number of basic questions are asked about fears and depression.)

FUNCTIONS OF THE CARDIOVASCULAR AND RESPIRATORY SYSTEMS

Functions of the cardiovascular system

Yes Blood pressure (systolic and diastolic (5x 10 min. and mean))

Yes Heart rate

Yes Heart rate at rest

Functions of the respiratory system

Yes Respiratory functions (Spirometric test)

Administration mode

Legend Yes No

Administration environment

Yes Hospital, clinic, university or recruitment center

Yes Participant residence

No Other

Staff administering test

Yes Professionals (nurses, clinicians, etc)

Yes Interviewers/research assistants

No Other

Documentation on procedures

Administration language Dutch

Utilization conditions

SOPs are in Dutch, and describe generally accepted procedures

Standard operating procedures (SOPs) or reference information

This Catalogue was archived on: 2013-12-09. Information included in this Catalogue is for informational purposes only.

General Information

Study name LifeLines Cohort Study & Biobank [LifeLines]
Last update 08/13/2012

Contact

Ronald P. Stolk (Chief Scientific Officer)
University Medical Center Groningen
Groningen 9700 RB
Phone: +31-50-361-1879
Email: r.p.stolk@umcg.nlMail

Samples

Legend Yes No
Sample name Blood
  Main laboratory
  Sample labels/traceability (% of samples)
  • No RFID radio frequency identification
  • Yes Barcode
  • Yes Printed labels
  • No Handwritten numbers
  • No Others
Pre-extraction sample storage format Substrate storage condition
  • Yes Fresh
  • No Refrigerated
  • Yes Frozen
  • Yes Dried (paper)
  • No Liquid Nitrogen
  • No Other
Substrate storage period
  • No Short term
  • No Long term
DNA extraction DNA extraction method
  • Yes Salting out
  • No Phenol-chloroform
  • No Columnary-extraction
  • No Magnetic beads
  • No Oragene (saliva)
  • No Others
Automation of handling
  • No Manual
  • Yes Automated
DNA handling and storage DNA diluent
  • No TE
  • No H2O
  • No Others
DNA concentration (ng/µl)
Storage conditions
  • Yes 4°C
  • No -20°C
  • No -40°C
  • Yes -80°C
  • No Dried
  • No Others
DNA quantification Methods
  • Yes A260/A280
  • No Picogreen
  • Yes Nanodrop
  • No Others
Technical quality
  • Yes Automated
  • No Manual
  • No Reproducibility
DNA quality control Percentage of samples that are tested
DNA quality method
  • No Agarose gel
  • No PCR
  • No A260/A280 ratio
  • No Others
DNA analysis Platforms
  • No Gentoyping
  • No Sequencing
  • No Methylation
  • No CNVs
  • No CGH
  • No FISH
  • No Other
Technical quality
  • No Automated
  • No Manual
  • No Reproducibility

GENERAL INFORMATION

Study name LifeLines Cohort Study & Biobank [LifeLines]
Last update 08/17/2012

Contacts

Ronald P. Stolk (Chief Scientific Officer)
University Medical Centre Groningen
Groningen 9700 RB
Phone: +31-50-361-1879
Email: r.p.stolk@umcg.nlMail
Lifelines Research Office
University Medical Centre Groningen
Groningen 9713 BZ
Email: LLScience@umcg.nlMail

ACCESS

Legend Yes No

Data or samples can be accessed by researchers outside the study/biobank (i.e. a researcher who is not an internal researcher of the study/biobank with research privileges)

  • Yes Access to at least part of the collected data is available for researchers outside the study
  • Yes Access to at least part of the collected samples is available for researchers outside the study

Data/samples can leave the study/biobank facility/country under the policies and regulations of your study

Data

  • No Can leave study/biobank facility
  • No Can leave the country

Samples

  • Yes Can leave study/biobank facility
  • Yes Can leave the country

Yes Participants can be contacted for additional information or sampling

Restriction to the category/type of investigator requesting access to your study

There are no restriction related to the categories of investigators requesting access

Limitations regarding the scientific scope of the projects that can use the study's data/samples

  • Yes Scope of the projects using the data of the study is limited (The approach must fit within the purpose of LifeLines as stated in the LifeLines protocol.)
  • Yes Scope of the projects using the samples of the study is limited (The approach must fit within the purpose of LifeLines as stated in the LifeLines protocol.)

ADDITIONAL INFORMATIONS

Legend Yes No

Approval process leading to access

To grant access, the study requires approval/authorization/documents by the following entities of the applicant's institution

  • No Ethics committee of applicant's institution (or another organization having jurisdiction or required by local governance rules)
  • No Scientific committee of applicant's institution (or another organization having jurisdiction or required by local governance rules)
  • Unknown Others

To grant access, the study requires approval/authorization/documents by the following entities of the study

  • No Ethics committee having jurisdiction over the study/biobank
  • Yes Scientific committee having jurisdiction over the study/biobank
  • Yes Another local committee/organization relevant to the study (Data access committee to check for 1. Availability of data/samples; 2.Feasibility for organisation; 3. Degree of burden for the participant.)

Processes described are integrated as a single administrative process (one stop shop)

Information regarding fees to access data/samples

Data

  • No There are fixed fees to access data
  • Yes There are scalable costs to access data varying according to the investigator (e.g. national investigators, students, public/private institutions, etc.)

Samples

  • No There are fixed fees to access samples
  • Yes There are scalable fees to access samples varying according to the investigator (e.g. national investigators, students, public/private institutions, etc.)

To protect confidentiality, access will be provided in the following format

  • No Samples are anonymized (irreversible�destruction of the identity of the participant)
  • No Data is anonymised (irreversible�destruction of the identity of the participant)
  • Yes Samples are coded (identification by a code(s), with possible�reversible�process to identify the participant)
  • Yes Data are coded (identification by a code(s), with possible�reversible�process to identify the participant)

Additional information

A contract will give the right to use the data for a pre-determined period of time. This contract also comprises the costs, which the investigator needs to reimburse and that are depending on the different LifeLines services to apply for.

Investigators will be have to

  • Yes Submit their publications (articles, presentation, etc) to the study for review prior to public disclosure
  • No Periodically report to the study on the uses of data/samples and/or publications made possible thanks to the use of this research material
  • Yes Recognize the study as a co-author on their publication
  • Yes Acknowledge the study in their publication (either in the text or in the footnotes)
  • Yes Others (All publications must include "LifeLines Cohort Study" or ”LifeLines” in the title or abstract text to make LifeLines visible in PubMed searches.)

Additional information

Other important conditions at http://www.lifelines.nl/lifelines-research/access-to-lifelines/publication-rules.

Study in-house analysis services

  Offered Mandatory
In-house laboratory analysis for applicants Yes No
In-house statistical analysis for applicants Yes No

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