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Nutrinet-Santé Study [NUTRINET-SANTE] Download as PDF

GENERAL INFORMATION

Name Nutrinet-Santé Study
Acronym NUTRINET-SANTE
Last update 11/12/2012

Affiliation

Principal investigators

Pilar Galan (MD, PhD)
Inserm U557/Inra/Cnam/P13
Sebastien Czernichow (MD, PhD)
Inserm U557/Inra/Cnam/P13
Katia Castetbon (PhD)
Inserm U557/Inra/Cnam/P13 and InVS
Serge Hercberg (M.D., PhD / PI)
Inserm U557/Inra/Cnam/P13

Contact

Serge Hercberg (M.D., PhD / PI)
Inserm U557/Inra/Cnam/P13
Phone: 33148388932
Email: hercberg@uren.smbh.univ-paris13.frMail

Website

Funding agencies

  • Institut National de la prévention et de l'éducation pour la santé, INPES
  • Fondation pour la recherche médicale (FRM)
  • Institut de veille sanitaire
  • Ministère de la santé, France
  • Institut de recherche en santé publique-IRESP

OBJECTIVES

The objectives of the NutriNet-Santé Study are:
1) to investigate the relationship between nutrition (nutrients, foods, dietary patterns, physical activity, nutritional status) and health outcome (incidence of cardiovascular diseases, cancers, diabetes, obesity, hypertension, mortality, etc.); and
2) to study the role of various determinants (sociological, economic, cultural, biochemical, cognitive, perception, food preferences, etc.) of dietary patterns and nutritional status and their interactions.

Research Focus

  • No Broad approach with no specific target of interest (study built as an infrastructure for a broad range of unspecified scientific activities/questions).
  • Yes Target specific questions of interest (predefined scientific targets like, cardiovascular diseases, social environment, specific health trajectories etc.) (nutrition, cancers, cardiovascular diseases, obesity, diabetes, hypertension, metabolic syndrome, quality of life, cognition, elderly, ...)
Topics ICD-10 classificationExternal
Yes Endocrine, nutritional and metabolic diseases (E00-E90)
Yes Diseases of the circulatory system (I00-I99)
Yes Diseases of the skin and subcutaneous tissue (L00-L99)

METHODS

Legend Yes No Unknown

General design

Study design Cohort
Type of participants Individuals
Target or final number of participants 500000
Target or final number of DNA 235000

Participant selection / Characteristics of the population

Selection criteria

Yes Age Minimun: 18 years   
Yes Country of residence France

Supplementary informations

Access to internet

Data Sources

  Cross-sectional Longitudinal follow-up
Yes Questionnaires to participants/respondents No Yes
Yes Direct physical measures No Yes
Yes Biological samples Yes No

Sample management

Biological samples

Yes Blood No Buccal cells
No Cord blood Unknown Tissues
No Saliva Yes Urine

Genome-Wide Association (GWA) analyses

  • Yes Plan to proceed to GWA analyses later

GOVERNANCE

Legend Yes No

Allow access to data or samples to external researchers

Yes Data (questionnaire-derived, measured…)
Yes Biological samples

STATUS

Current status

Phase Start End
Preparation phase/Pilot 2009 2009
Baseline recruitment / initial data collection 2009 2014
Follow-up of participants 2009 2019
Study ended   2019
Current number of participants recruited 115000 in date of 11/11/2012
Current number of collected DNA samples 9500 in date of 11/11/2012

Buffy coats


General Information

Study name Nutrinet-Santé Study [NUTRINET-SANTE]
Last update 02/23/2008

Contact

Pilar Galan (MD, PhD)
 Inserm U557/Inra/Cnam/P13
Bobigny F-93017
Phone: 33 1 48 38 89 32
Email: p.galan@uren.smbh.univ-paris13.frMail

Quality Management Steps

Yes Sampling (LIMS-nautilus)
Yes Shipment (LIMS-nautilus)
Yes Processing (LIMS-nautilus)
Yes Storage (LIMS-nautilus)
Yes Distribution (LIMS-nautilus)
Yes Data Management and IT (LIMS-nautilus)

Comments

Blood collection will start in December 2010 (collection planned on 5 years). In the first step, only buffy coat will be available. DNA extraction is planned in a second step.

Samples

Legend Yes No
Sample name Blood
  Main laboratory
  Sample labels/traceability (% of samples)
  • No RFID radio frequency identification
  • Yes Barcode (2D)
  • No Printed labels
  • No Handwritten numbers
  • No Others
Pre-extraction sample storage format Substrate storage condition
  • No Fresh
  • No Refrigerated
  • Yes Frozen (-80°C)
  • No Dried (paper)
  • No Liquid Nitrogen
  • No Other
Substrate storage period
  • No Short term
  • Yes Long term (+C5)
DNA extraction DNA extraction method
  • No Salting out
  • No Phenol-chloroform
  • No Columnary-extraction
  • No Magnetic beads
  • No Oragene (saliva)
  • No Others
Automation of handling
  • No Manual
  • No Automated
DNA handling and storage DNA diluent
  • No TE
  • No H2O
  • No Others
DNA concentration (ng/µl)
Storage conditions
  • No 4°C
  • No -20°C
  • No -40°C
  • No -80°C
  • No Dried
  • No Others
DNA quantification Methods
  • No A260/A280
  • No Picogreen
  • No Nanodrop
  • No Others
Technical quality
  • No Automated
  • No Manual
  • No Reproducibility
DNA quality control Percentage of samples that are tested
DNA quality method
  • No Agarose gel
  • No PCR
  • No A260/A280 ratio
  • No Others
DNA analysis Platforms
  • No Gentoyping
  • No Sequencing
  • No Methylation
  • No CNVs
  • No CGH
  • No FISH
  • No Other
Technical quality
  • No Automated
  • No Manual
  • No Reproducibility

General Information

Study name Nutrinet-Santé Study [NUTRINET-SANTE]
Last update 03/18/2009

Contact

Pilar Galan (MD, PhD)
Inserm U557/Inra/Cnam/P13
Bobigny F-93017
Phone: 33 1 48 38 89 32
Email: p.galan@uren.smbh.univ-paris13.frMail

Software

Legend Yes No

Software overview

Biobanking areas covered SAS 9.1.3External Thermo nautilus LIMSExternal (SAAS) Med Passport v.3.8External
Participant recruitment (ex: CATI, CRM) Yes
Data collection Yes Yes
Sample collection, storage and processing Yes Yes
Data repository Yes Yes
Other
 
Programming language SAS 9.1.3External Thermo nautilus LIMSExternal (SAAS) Med Passport v.3.8External
Name and version of programming language sas dotNet Framework
 
Internal/external development SAS 9.1.3External Thermo nautilus LIMSExternal (SAAS) Med Passport v.3.8External
In-house by IT department
By an external company Yes Yes Yes
 
Shareability SAS 9.1.3External Thermo nautilus LIMSExternal (SAAS) Med Passport v.3.8External
Freely available
Purchaseable Yes Yes
Needs extensive work
Not for share Yes

Software details

Biobanking areas covered

  • No Participant recruitment (ex: CATI, CRM)
  • No Data collection
  • No Questionnaires (ex: CAPI)
  • No Physical and cognitive measures
  • No Sample collection, storage and processing
  • No Collection
  • No Sample bio-repository management system (ex: sample storage management software)
  • No LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • Yes Data repository
  • Yes Data warehousing
  • No Study monitoring (ex: quality control)
  • Yes User data / sample request management

Name and version of programming language

sas

Internal/external development

  • No In-house by IT department
  • Yes By an external company (SAS Institute Inc)

Shareability

  • No Freely available
  • Yes Purchaseable
  • No Needs extensive work
  • No Not for share

Url

Biobanking areas covered

  • No Participant recruitment (ex: CATI, CRM)
  • Yes Data collection
  • Yes Questionnaires (ex: CAPI)
  • Yes Physical and cognitive measures
  • Yes Sample collection, storage and processing
  • Yes Collection
  • No Sample bio-repository management system (ex: sample storage management software)
  • Yes LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • Yes Data repository
  • Yes Data warehousing
  • Yes Study monitoring (ex: quality control)
  • Yes User data / sample request management

Internal/external development

  • No In-house by IT department
  • Yes By an external company (Thermo Fisher)

Shareability

  • No Freely available
  • Yes Purchaseable
  • No Needs extensive work
  • No Not for share

Url

Biobanking areas covered

  • Yes Participant recruitment (ex: CATI, CRM)
  • Yes Data collection
  • Yes Questionnaires (ex: CAPI)
  • No Physical and cognitive measures
  • Yes Sample collection, storage and processing
  • Yes Collection
  • No Sample bio-repository management system (ex: sample storage management software)
  • No LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • No Data repository
  • No Data warehousing
  • No Study monitoring (ex: quality control)
  • No User data / sample request management

Name and version of programming language

dotNet Framework

Internal/external development

  • No In-house by IT department
  • Yes By an external company (Voluntis)

Shareability

  • No Freely available
  • No Purchaseable
  • No Needs extensive work
  • Yes Not for share

Url

Comments

Blood collection will start December 2010

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