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Taiwan Biobank Download as PDF

GENERAL INFORMATION

Name Taiwan Biobank
Last update 05/22/2008

Principal investigators

Chen-Yang Shen (Dr)
Taiwan Biobank, N803, Institute of Biomedical Sciences
Yuan-Tsong Chen (Dr)
Institute of Biomedical Sciences Academia Sinica

Contact

Chen-Yang Shen (Dr)
Taiwan Biobank, N803, Institute of Biomedical Sciences
Taipei 115
Phone: 886-2-2789-9036
Email: bmcys@ibms.sinica.edu.twMail

Website

No information available

Funding agency

  • Department of Health, Executive Yuan, ROC

BACKGROUND

With the advancement in the biomedical research and the completion of the human genome sequencing, geneticists now provide biomedical researchers with a wider variety of disease information than before, further aiding researchers in more in-depth researches on disease causing mechanisms. Numerous countries have already begun active participation in the construction of their own Biobanks with the goal of creating a large population-based cohort database, allowing combination of genetics and other medical information. It is therefore highly beneficial for Taiwan to construct a Biobank specific for the local population, as it would enable large scale cohort studies to be carried out for common diseases occurring locally in Taiwan.

OBJECTIVES

To investigate the gene factors behind common chronic diseases in Taiwan, such as cancer, high blood pressure and diabetes, and the interaction of genetic and external risk factors. external risk factors.

METHODS

Legend Yes No Unknown

General design

Study design Cohort
Type of participants Individuals
Target or final number of participants 15000
Target or final number of DNA 15000

Participant selection / Characteristics of the population

Selection criteria

Yes Age Minimun: 30 years    Maximun: 70 years
Yes Country of residence Taiwan (Chiayi, Hualien, Miaoli)
Yes Ethnic origin (Taiwanese population)

Recruitment procedures

The assessment of recruitment including poster exhibition、information leaflet and assemblage of recruitment.

Data Sources

  Cross-sectional Repeated/continuous
Yes Questionnaires to participants/respondents No Yes
Yes Direct physical measures No Yes
Yes Biological samples No Yes
No Medical paper
No Electronic databases
No Genealogical records  

Collection procedures

1.Collection of biospecimen: blood and urine；2.Physical exams；3.Questionnaires；4.Data & sample storage.

Follow up procedures

The frequency of follow-up：Once every four years. Follow-up procedures are similar initial data collection procedures.

Baseline principal variables of interest

Health information

  • Yes Diseases history - ICD-10
  • Yes Familial disease history
  • No Early life
  • Yes Women's health
  • No Quality of life

Physical / Biochemical measures

Yes Body structure measures Yes Biochemical measures
Yes Body function measures  

Sociodemographic Characteristics

Yes Ethnicity/Race Yes Gender
Yes Marital status Yes Date of birth

Socioeconomic Characteristics

Yes Education level Yes Income
Yes Working status  

Life habits / Behaviours

Yes Physical activity Yes Smoking / Tobacco Use
Yes Nutrition Yes Alcohol intake

Physical environment

Yes Passive smoking No Mobile phone use

Sample management

Biological samples

Yes Blood No Buccal cells
No Cord blood No Tissues
No Saliva Yes Urine

Biological samples format

  Fresh Frozen Dried (paper) Other Specification
Blood Yes No No No

GOVERNANCE

Legend Yes No

Allow access to data or samples to external researchers

Yes Data (questionnaire-derived, measured…)
Yes Biological samples

STATUS

Current status

Phase Start End
Preparation phase/Pilot 2003 2007
Recruitment / initial data collection 2005 2009
Follow-up of participants -- --
Current number of participants recruited --
Current number of collected DNA samples --

AVAILABLE DOCUMENTS

  Document type Availability
1 General study protocol biobank@gate.sinica.edu.twMail
2 Specific protocols/procedures (data collection, samples management, etc.) biobank@gate.sinica.edu.twMail
3 Questionnaires biobank@gate.sinica.edu.twMail
4 Physical and cognitive measures
5 DNA processing
6 Consent forms biobank@gate.sinica.edu.twMail
7 Pamphlet / project description
8 Governance / ethics documentation
9 Other

General information

Name Physical and cognitive measures
Last update 11/06/2008

Contact

Chen-Yang Shen (Dr)
Institute of Biomedical Sciences Academia Sinica
Taipei 115
Phone: 886-2-2789-9036
Email: bmcys@ibms.sinica.edu.twMail

Physical and cognitive measures collected

Legend Yes No

BODY STRUCTURES

ANTHROPOMETRIC STRUCTURES

Anthropometric measures

Yes Weight

Yes Height

Yes Standing height

Yes Body circumferences

Yes Waist circumference

Yes Hip circumference

Body composition

Yes Bone density

BODY FUNCTIONS

FUNCTIONS OF THE CARDIOVASCULAR AND RESPIRATORY SYSTEMS

Functions of the cardiovascular system

Yes Blood pressure

Yes Heart rate

Yes Heart rate at rest

Functions of the respiratory system

Yes Respiratory functions

Administration mode

Legend Yes No

Administration environment

Yes Hospital, clinic, university or recruitment center

No Participant residence

No Other

Staff administering test

Yes Professionals (nurses, clinicians, etc)

No Interviewers/research assistants

No Other

Documentation on procedures

Administration language Chinese

General Information

Name DNA Processing
Study name Taiwan Biobank
Last update 03/29/2010

Contact

Chen-Yang Shen (Dr)
 Institute of Biomedical Sciences Academia Sinica
Taipei 115
Phone: 886-2-2789-9036
Email: bmcys@ibms.sinica.edu.twMail
Utilization conditions No

Quality Management Steps

Yes Sampling
Yes Shipment
Yes Processing
Yes Storage

Samples

Legend Yes No
Sample name Blood
  Main laboratory The lab of Taiwan Biobank, Institute of Biomedical Sciences (IBMS), Academia Sinica
  Sample labels/traceability (% of samples)
  • No RFID radio frequency identification
  • Yes Barcode (1D , 2D)
  • Yes Printed labels
  • No Handwritten numbers
  • No Others
Pre-extraction sample storage format Substrate storage condition
  • No Fresh
  • Yes Refrigerated (4 °C)
  • No Frozen
  • Yes Dried (paper)
  • No Liquid Nitrogen
  • No Other
Substrate storage period
  • No Short term
  • No Long term
Protocols
DNA extraction DNA extraction method
  • No Salting out
  • No Phenol-chloroform
  • No Columnary-extraction
  • Yes Magnetic beads
  • No Oragene (saliva)
  • No Others
Automation of handling
  • No Manual
  • Yes Automated
Protocols
DNA handling and storage DNA diluent
  • Yes TE
  • Yes H2O
  • No Others
DNA concentration (ng/µl)
Storage conditions
  • Yes 4°C (1-7 days)
  • No -20°C
  • No -40°C
  • Yes -80°C (Long term)
  • Yes Dried
  • No Others
Protocols DNA concentration varies from 100~885 ng/ul.
DNA quantification Methods
  • Yes A260/A280
  • No Picogreen
  • Yes Nanodrop
  • No Others
Technical quality
  • Yes Automated
  • No Manual
  • Yes Reproducibility
DNA quality control Percentage of samples that are tested 100.0
DNA quality method
  • Yes Agarose gel
  • No PCR
  • Yes A260/A280 ratio
  • No Others
Protocols

General Information

Name Information Technologies
Study name Taiwan Biobank
Last update 01/06/2010

Contact

Belinda Chen
Institute for Information Industry
Taipei 105
Phone: 886-2-27139000 ext.371
Email: klchen@iii.org.twMail

Software

Legend Yes No

Software overview

Biobanking areas covered Document Management System Questionnaire System Statistical Analysis and Reporting System Privacy Control System Participant Recruitment System LabVantage Sapphire LIMS R5
Participant recruitment (ex: CATI, CRM) Yes
Data collection Yes Yes
Sample collection, storage and processing Yes
Data repository Yes Yes Yes Yes Yes Yes
Other
 
Programming language Document Management System Questionnaire System Statistical Analysis and Reporting System Privacy Control System Participant Recruitment System LabVantage Sapphire LIMS R5
Name and version of programming language Java 1.5, JSP Java 1.4.2, SQL Java 1.5, JSP Java 1.5, JSP Java 1.5, JSP, SQL Java 1.5, Javascripts, SQL
 
Internal/external development Document Management System Questionnaire System Statistical Analysis and Reporting System Privacy Control System Participant Recruitment System LabVantage Sapphire LIMS R5
In-house by IT department Yes Yes Yes Yes Yes
By an external company Yes
 
Shareability Document Management System Questionnaire System Statistical Analysis and Reporting System Privacy Control System Participant Recruitment System LabVantage Sapphire LIMS R5
Freely available
Purchaseable Yes
Needs extensive work
Not for share Yes Yes Yes Yes Yes

Software details

Biobanking areas covered

  • No Participant recruitment (ex: CATI, CRM)
  • No Data collection
  • No Questionnaires (ex: CAPI)
  • No Physical and cognitive measures
  • No Sample collection, storage and processing
  • No Collection
  • No Sample bio-repository management system (ex: sample storage management software)
  • No LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • Yes Data repository
  • Yes Data warehousing
  • No Study monitoring (ex: quality control)
  • Yes User data / sample request management

Name and version of programming language

Java 1.5, JSP

Internal/external development

  • Yes In-house by IT department
  • No By an external company

Shareability

  • No Freely available
  • No Purchaseable
  • No Needs extensive work
  • Yes Not for share

Biobanking areas covered

  • No Participant recruitment (ex: CATI, CRM)
  • Yes Data collection
  • Yes Questionnaires (ex: CAPI)
  • No Physical and cognitive measures
  • No Sample collection, storage and processing
  • No Collection
  • No Sample bio-repository management system (ex: sample storage management software)
  • No LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • Yes Data repository
  • Yes Data warehousing
  • Yes Study monitoring (ex: quality control)
  • Yes User data / sample request management

Name and version of programming language

Java 1.4.2, SQL

Internal/external development

  • Yes In-house by IT department
  • No By an external company

Shareability

  • No Freely available
  • No Purchaseable
  • No Needs extensive work
  • Yes Not for share

Biobanking areas covered

  • No Participant recruitment (ex: CATI, CRM)
  • No Data collection
  • No Questionnaires (ex: CAPI)
  • No Physical and cognitive measures
  • No Sample collection, storage and processing
  • No Collection
  • No Sample bio-repository management system (ex: sample storage management software)
  • No LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • Yes Data repository
  • Yes Data warehousing
  • Yes Study monitoring (ex: quality control)
  • No User data / sample request management

Name and version of programming language

Java 1.5, JSP

Internal/external development

  • Yes In-house by IT department
  • No By an external company

Shareability

  • No Freely available
  • No Purchaseable
  • No Needs extensive work
  • Yes Not for share

Biobanking areas covered

  • No Participant recruitment (ex: CATI, CRM)
  • No Data collection
  • No Questionnaires (ex: CAPI)
  • No Physical and cognitive measures
  • No Sample collection, storage and processing
  • No Collection
  • No Sample bio-repository management system (ex: sample storage management software)
  • No LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • Yes Data repository
  • No Data warehousing
  • No Study monitoring (ex: quality control)
  • Yes User data / sample request management

Name and version of programming language

Java 1.5, JSP

Internal/external development

  • Yes In-house by IT department
  • No By an external company

Shareability

  • No Freely available
  • No Purchaseable
  • No Needs extensive work
  • Yes Not for share

Biobanking areas covered

  • Yes Participant recruitment (ex: CATI, CRM)
  • Yes Data collection
  • No Questionnaires (ex: CAPI)
  • Yes Physical and cognitive measures
  • No Sample collection, storage and processing
  • No Collection
  • No Sample bio-repository management system (ex: sample storage management software)
  • No LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • Yes Data repository
  • Yes Data warehousing
  • No Study monitoring (ex: quality control)
  • Yes User data / sample request management

Name and version of programming language

Java 1.5, JSP, SQL

Internal/external development

  • Yes In-house by IT department
  • No By an external company

Shareability

  • No Freely available
  • No Purchaseable
  • No Needs extensive work
  • Yes Not for share

Biobanking areas covered

  • No Participant recruitment (ex: CATI, CRM)
  • No Data collection
  • No Questionnaires (ex: CAPI)
  • No Physical and cognitive measures
  • Yes Sample collection, storage and processing
  • Yes Collection
  • Yes Sample bio-repository management system (ex: sample storage management software)
  • Yes LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • Yes Data repository
  • Yes Data warehousing
  • Yes Study monitoring (ex: quality control)
  • Yes User data / sample request management

Name and version of programming language

Java 1.5, Javascripts, SQL

Internal/external development

  • No In-house by IT department
  • Yes By an external company

Shareability

  • No Freely available
  • Yes Purchaseable
  • No Needs extensive work
  • No Not for share

Comments

No information available

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