Home > Catalogues

Kadoorie Study of Chronic Disease in China [KSCDC] Download as PDF

GENERAL INFORMATION

Name Kadoorie Study of Chronic Disease in China
Acronym KSCDC
Last update 02/05/2010

Principal investigators

Liming Lee (Prof.)
China Centre for Disease Control, China
Zhengming Chen (Prof.)
Clinical Trial Service Unit & Epidemiological Studies Unit, Oxford University, United Kingdom

Contacts

Liming Lee (Prof.)
Perking Union Medical College, Chinese Academy of Medical Sciences
Beijing 100730
Email: lmlee@vip.163.comMail
Zhengming Chen (Prof.)
Clinical Trial Service Unit & Epidemiological Studies Unit
Oxford OX3 7LF
Phone: +44-1865-743743
Email: Zhengming.chen@ctsu.ox.ac.ukMail

Website

Funding agencies

  • Cancer Research UK
  • The British Heart Foundation
  • UK-based support from the Medical Research Council
  • Hong Kong-based Kadoorie Charitable Foundation (KCF)

BACKGROUND

During recent decades China has undergone a rapid transition in the main disease patterns of its population. There has been a substantial decrease in maternal and child mortality and in adult mortality from the main infectious/parasitic diseases, whereas for ischaemic heart disease and some other non-communicable chronic diseases, there has been a moderate increase in mortality rates, at least in some parts of China. Consequently, most of the premature mortality that still remains in China now involves the chronic diseases of middle age, such as cancer, stroke, heart disease, or chronic lung disease. For each major disease there are large unexplained variations in the age-specific rates between different parts of China, indicating that there must be some large avoidable causes. Large blood-based prospective studies are important ways of investigating many slow-acting causes of the common chronic diseases in the population.

OBJECTIVES

The principal aim of the study is to assess reliably the effects of both established risk factors (such as smoking, alcohol, obesity, etc) and emerging risk factors (eg, genetic markers) for many different diseases, not only overall but also in a range of different circumstances (e.g., at different ages and at different levels of other risk factors).

METHODS

Legend Yes No Unknown

General design

Study design Cohort
Type of participants Individuals
Target or final number of participants 500000
Target or final number of DNA 500000

Participant selection / Characteristics of the population

Selection criteria

Yes Age Minimun: 30 years    Maximun: 79 years
Yes Country of residence China (Residents of 10 Chinese regions.)
Yes Other criteria Participants were selected according to disease, exposure and demographic profiles as well as availability of research facilities.

Recruitment procedures

In the 10 study areas, all men and women aged 35–74 who are permanently resident (for complete follow-up of mortality and morbidity) and without major disability in each administrative unit (village or street committee) will be identified and invited to participate.

Data Sources

  Cross-sectional Repeated/continuous
Yes Questionnaires to participants/respondents Yes Yes
Yes Direct physical measures Yes Yes
Yes Biological samples Yes Yes
No Medical paper
Yes Electronic databases
No Genealogical records  

Collection procedures

Following informed written consent, each study participant will undergo an interview and physical examination and will provide a blood sample for long-term storage. Information collected through face-to-face interview will cover a broad range of variables, and many physical aspects are also to be measured.

Follow up procedures

At 5 year intervals, a reasonably representative sample of ~15 000 (3%) surviving study participants will be invited for re-survey with repeat interviews, including the same measurements and blood collection procedures as those in the baseline survey. All study participants will be followed-up indefinitely for cause-specific mortality and for any hospitalised event through the death registries and health insurance claim systems that are now fully established at the 10 study sites.

Baseline principal variables of interest

Health information

  • Yes Diseases history - ICD-10
  • Yes Familial disease history
  • No Early life
  • Yes Women's health
  • No Quality of life

Physical / Biochemical measures

Yes Body structure measures Yes Biochemical measures
Yes Body function measures  

Sociodemographic Characteristics

No Birth location No Parents birth location
Yes Ethnicity/Race Yes Gender
Yes Marital status Yes Date of birth

Socioeconomic Characteristics

Yes Education level Yes Income
Yes Working status  

Life habits / Behaviours

Yes Physical activity Yes Smoking / Tobacco Use
Yes Nutrition Yes Alcohol intake

Physical environment

Yes Passive smoking No Mobile phone use

Sample management

Biological samples

Yes Blood No Buccal cells
No Cord blood No Tissues
Unknown Saliva Unknown Urine

Biological samples format

  Fresh Frozen Dried (paper) Other Specification
Blood No Yes No No

Genome-Wide Association (GWA) analyses

  • Yes Plan to proceed to GWA analyses later

GOVERNANCE

Legend Yes No

Allow access to data or samples to external researchers

Yes Data (questionnaire-derived, measured…)
Yes Biological samples

STATUS

Current status

Phase Start End
Preparation phase/Pilot -- --
Recruitment / initial data collection 2004 2008
Follow-up of participants 2004 2025
Current number of participants recruited 513211 in date of 01/01/2010
Current number of collected DNA samples 513116 in date of 01/01/2010

AVAILABLE DOCUMENTS

  Document type Availability
1 General study protocol Zhengming.chen@ctsu.ox.ac.ukMail
2 Specific protocols/procedures (data collection, samples management, etc.) Zhengming.chen@ctsu.ox.ac.ukMail
3 Questionnaires Zhengming.chen@ctsu.ox.ac.ukMail
4 Physical and cognitive measures Zhengming.chen@ctsu.ox.ac.ukMail
5 DNA processing
6 IT
7 Ethics
8 Consent forms Zhengming.chen@ctsu.ox.ac.ukMail
9 Pamphlet / project description Zhengming.chen@ctsu.ox.ac.ukMail
10 Governance / ethics documentation Zhengming.chen@ctsu.ox.ac.ukMail
11 Other

PUBLICATIONS AND RELEVANT DOCUMENTATION

1
Peto, Linksted, Lee, Chen, Wu, Chen, Guo, Collins Cohort profile: the Kadoorie Study of Chronic Disease in China (KSCDC). International journal of epidemiology 2005 1243-9


General Information

Name Kadoorie Study of Chronic Disease in China Questionnaire
Last update 03/18/2009
Version or reference year 2004

Questionnaire owner

  • Clinical Trial Service Unit & Epidemiological Studies Unit, University of Oxford

Contact

Zhengming Chen (Prof.)
Clinical Trial Service Unit & Epidemiological Studies Unit
Oxford OX3 7LF
Phone: +44-1865-743743
Email: Zhengming.chen@ctsu.ox.ac.ukMail

Utilization conditions

Permission should be sought in advance.

Information on validity

A re-survey will be undertaken in 3-5% of the study participants, which will provide useful information about the validity of the questionnaire data collected.

References

Methods

Legend Yes No

Respondent

  • Yes Participant
  • No Proxy

Administration environment

  • No Over the phone
  • Yes Hospital, clinic, university or recruitment center
  • No Respondent / Proxy residence

Administration mode

  • No Auto administered
  • No Auto administrated with face to face validation by trained personnel
  • Yes Administrated by trained personel / Physician

Administration format

  • No Paper questionnaire
  • Yes Computerized

Administration language

  • Chinese
  • English

Documents

Available Format

  • Adapted questionnaireWeb page
  • Original questionnairePDF

NOTICE: HTML document format may differ slightly from the actual questionnaire. Please refer to the original PDF document for exact reproduction.

General Information

Name Kadoorie Study of Chronic Disease in China Questionnaire
Number of Question Blocks 37

Questionnaire and Question Block List

Click on the View block to see the block of questions related to a domain or a group of domains.
Block 1 View block
  • Sociodemographic Characteristics / Gender
Block 2 View block
  • Sociodemographic Characteristics / Age/Birth Date / Subject age / birth date
Block 3 View block
  • Sociodemographic Characteristics / Residence / Current Residence
Block 4 View block
  • Socioeconomic Characteristics / Education level / Subject education level
Block 5 View block
  • Socioeconomic Characteristics / Working status / Subject Working status/history
Block 6 View block
  • Sociodemographic Characteristics / Household Status / Structure of the Household
Block 7 View block
  • Sociodemographic Characteristics / Household Status / Subjet Household Status
Block 8 View block
  • Socioeconomic Characteristics / Income
Block 9 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Beverages (other than water or alcohol)
Block 10 View block
  • Life Habits/Behaviours / Alcohol use
Block 11 View block
  • Life Habits/Behaviours / Tobacco use
Block 12 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Cereals, Bread, Starches
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Meat, Eggs, Fish and Alternatives
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Milk products
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Vegetables and Fruits
Block 13 View block
  • Health Information / Medication Intake (ATC/DDD) / Various
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Salt and Food Supplement
Block 14 View block
  • Life Habits/Behaviours / Nutrition / Nutritional Behaviours and Perception of Nutritional Habits
  • Life Habits/Behaviours / Weight related behaviours
Block 15 View block
  • Physical Environment / Environmental exposures / Chemical environmental exposures / Passive Smoke Exposure
  • Physical Environment / Occupational Exposures / Chemical Occupational Exposures / Passive Smoke Exposure
Block 16 View block
  • Life Habits/Behaviours / Nutrition / Nutritional Behaviours and Perception of Nutritional Habits
  • Physical Environment / Environmental exposures / Chemical environmental exposures
Block 17 View block
  • Health Information / Perception of health/quality of life
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving the circulatory and respiratory systems
  • Life Habits/Behaviours / Physical activity / Perception of physical health
Block 18 View block
  • Health Information / Individual Disease history / Certain infectious and parasitic diseases
  • Health Information / Individual Disease history / Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
  • Health Information / Individual Disease history / Diseases of the circulatory system
  • Health Information / Individual Disease history / Diseases of the digestive system
  • Health Information / Individual Disease history / Diseases of the genitourinary system
  • Health Information / Individual Disease history / Diseases of the musculoskeletal system and connective tissue
  • Health Information / Individual Disease history / Diseases of the nervous system
  • Health Information / Individual Disease history / Diseases of the respiratory system
  • Health Information / Individual Disease history / Endocrine, nutritional and metabolic diseases
  • Health Information / Individual Disease history / Injury, poisoning and certain other consequences of external causes
  • Health Information / Individual Disease history / Mental and behavioural disorders
  • Health Information / Individual Disease history / Neoplasms
  • Health Information / Medication Intake (ATC/DDD) / Alimentary tract and metabolism (A)
  • Health Information / Medication Intake (ATC/DDD) / Blood and blood forming organs (B)
  • Health Information / Medication Intake (ATC/DDD) / Cardiovascular system (C)
  • Health Information / Medication Intake (ATC/DDD) / Musculo-skeletal system (M)
  • Health Information / Medication Intake (ATC/DDD) / Nervous system (N)
Block 19 View block
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Cardiovascular System
Block 20 View block
  • Health Information / Medical Health Intervention (C239) / Clinical Laboratory Interventions
Block 21 View block
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving the digestive system and abdomen
Block 22 View block
  • Health Information / Reproductive history / Number of children
  • Sociodemographic Characteristics / Kinship
Block 23 View block
  • Social Environment / Familial and social environment
Block 24 View block
  • Health Information / Familial Disease History (ICD10*) / Diseases of the circulatory system
  • Health Information / Familial Disease History (ICD10*) / Endocrine, nutritional and metabolic diseases
  • Health Information / Familial Disease History (ICD10*) / Mental and behavioural disorders
  • Health Information / Familial Disease History (ICD10*) / Neoplasms
Block 25 View block
  • Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency
Block 26 View block
  • Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency
  • Socioeconomic Characteristics / Working status / Subject Working status/history
Block 27 View block
  • Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency
Block 28 View block
  • Body structures / Anthropometric structures / Anthropometric measures / Weight
  • Life Habits/Behaviours / Weight related behaviours
Block 29 View block
  • Health Information / Women's health / Menstruation
Block 30 View block
  • Health Information / Women's health / Menopause
Block 31 View block
  • Health Information / Medical Health Intervention (C239) / Obstetrical and Fetal Interventions / Anteparturn Obstetrical Interventions
  • Health Information / Medical Health Intervention (C239) / Obstetrical and Fetal Interventions / Termination of Pregnancy
  • Health Information / Reproductive history / Number of children
  • Health Information / Reproductive history / Parity/Gravidity
Block 32 View block
  • Health Information / Women's health / Breast feeding
Block 33 View block
  • Health Information / Medication Intake (ATC/DDD) / Genito urinary system and sex hormones (G)
Block 34 View block
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Genitourinary System
Block 35 View block
  • Health Information / Perception of health/quality of life
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving cognition, perception, emotional state and behaviour
Block 36 View block
  • Life Habits/Behaviours / Sleep Behaviours
Block 37 View block
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving cognition, perception, emotional state and behaviour

General information

Name Physical and cognitive measures
Last update 06/19/2009
Collected at phase Baseline

Contacts

Zhengming Chen (Prof.)
Oxford OX3 7LF
Phone: +44-1865-743743
Email: Zhengming.chen@ctsu.ox.ac.ukMail

Physical and cognitive measures collected

Legend Yes No

BODY STRUCTURES

ANTHROPOMETRIC STRUCTURES

Anthropometric measures

Yes Weight

Yes Height

Yes Standing height

Yes Sitting height

Yes Body circumferences

Yes Waist circumference

Yes Hip circumference

Body composition

Yes Bioimpedance

Yes Others body composition measures (Fat percentage)

BODY FUNCTIONS

MENTAL FUNCTIONS

Global mental functions

Yes Cognitive functions (CIDI form)

FUNCTIONS OF THE CARDIOVASCULAR AND RESPIRATORY SYSTEMS

Functions of the cardiovascular system

Yes Blood pressure (At rest)

Yes Heart rate

Yes Heart rate at rest

Functions of the respiratory system

Yes Respiratory functions (Spirometry)

Yes Others measures of the respiratory system (CO level)

Administration mode

Legend Yes No

Administration environment

Yes Hospital, clinic, university or recruitment center

No Participant residence

No Other

Staff administering test

Yes Professionals (nurses, clinicians, etc)

Yes Interviewers/research assistants

No Other

Documentation on procedures

Administration language Chinese

Standard operating procedures (SOPs) or reference information

General Information

Name Information Technologies
Study name Kadoorie Study of Chronic Disease in China [KSCDC]
Last update 10/28/2008

Contacts

Garry Lancaster (Dr)
CTSU, Richard Doll Building, Old Road Campus, University of Oxford
Oxford
Phone: +44-1865-743 743
Email: garry.lancaster@ctsu.ox.ac.ukMail
Xiaoming Yang (Dr)
CTSU, Richard Doll Building, Old Road Campus, University of Oxford
Oxford
Phone: +44-1865-743 743
Email: xiaoming.yang@ctsu.ox.ac.ukMail

Software

Legend Yes No

Biobanking areas covered

  • Yes Participant recruitment (ex: CATI, CRM)
  • Yes Data collection
  • Yes Questionnaires (ex: CAPI)
  • Yes Physical and cognitive measures
  • Yes Sample collection, storage and processing
  • Yes Collection
  • Yes Sample bio-repository management system (ex: sample storage management software)
  • Yes LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • Yes Data repository
  • Yes Data warehousing
  • Yes Study monitoring (ex: quality control)
  • Yes User data / sample request management
  • Yes Other (1. Data transfer & replication, internal email systems, remote database management, stock control, equipment calibration management system, electronic linkage systems with death registrries, etc)

Name and version of programming language

C++ Builder 5

Internal/external development

  • Yes In-house by IT department
  • No By an external company

Shareability

  • Yes Freely available
  • No Purchaseable
  • Yes Needs extensive work
  • No Not for share

Comments

Overall we have developed over 30 applications to support the whole project, using various programming languages and IT tools. All of them were developed in house and we are happy to share our experience and softwares with other research groups.

© 2005 Public Population Project in Genomics.
All rights reserved.
Information Usage