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Singapore Consortium of Cohort Studies [SCCS] Download as PDF

GENERAL INFORMATION

Name Singapore Consortium of Cohort Studies
Acronym SCCS
Last update 08/19/2009

Affiliation

Principal investigators

ES Tai
Kee-Seng Chia (Dr.)
National University of Singapore

Contact

Kee-Seng Chia (Dr.)
National University of Singapore, Dep. of Community, Occupational and Family Medicine (MD3)
Singapore 117597
Phone: +65 65164971
Email: ephcks@nus.edu.sgMail

Website

Funding agency

  • government

BACKGROUND

The individual cohorts are not adequately powered to study ethnic differences in gene-environment interactions in diseases of public health significance. The Consortium aims at forming a large multi-ethnic cohort, with similar study protocol, consent procedures and IT, laboratory and tissue storage platforms.

OBJECTIVES

Discover gene-environment interactions of clinical and public health significance.

METHODS

Legend Yes No Unknown

General design

Study design Cohort
Type of participants Individuals
Target or final number of participants 22000
  SCCS will recruit 22,000 participants in this initial phase of the project. The plan is to eventually recruit a much larger cohort of Singaporeans over the next 10-20 years and maybe even longer.
Target or final number of DNA No information available

Participant selection / Characteristics of the population

Selection criteria

Yes Age Minimun: 21 years    Maximun: 65 years
Yes Country of residence Singapore

Recruitment procedures

Subjects identified by disproportionate sampling stratified by ethnicity are invited and visited by staff for consent and questionnaire. They are then invited to the clinic for additional tests and collection of biological specimens.

Data Sources

  Cross-sectional Repeated/continuous
Yes Questionnaires to participants/respondents Yes No
Yes Direct physical measures Yes No
Yes Biological samples Yes No
Yes Medical paper
No Electronic databases
No Genealogical records  

Follow up procedures

No information available

Baseline principal variables of interest

Health information

  • Yes Diseases history - ICD-10
  • Yes Familial disease history
  • No Early life
  • Yes Women's health

Physical / Biochemical measures

Yes Body structure measures Yes Biochemical measures
Yes Body function measures  

Sociodemographic Characteristics

Yes Birth location No Parents birth location
Yes Ethnicity/Race Yes Gender
Yes Marital status Yes Date of birth

Socioeconomic Characteristics

Yes Education level Yes Income
Yes Working status  

Life habits / Behaviours

Yes Physical activity Yes Smoking / Tobacco Use
Yes Nutrition Yes Alcohol intake

Physical environment

No Passive smoking

Sample management

Biological samples

Yes Blood No Buccal cells
No Cord blood No Tissues
Unknown Saliva Unknown Urine

Biological samples format

  Fresh Frozen Dried (paper) Other Specification
Blood No Yes No No

GOVERNANCE

Legend Yes No

Allow access to data or samples to external researchers

Unknown Data (questionnaire-derived, measured…)
Unknown Biological samples
Yes Other (- Organization(s) responsible for ethics review, and approval process:
IRB and host organizations

- Governing bodies and monitoring processes (external & internal):
IRB)

STATUS

Current status

Phase Start End
Preparation phase/Pilot -- --
Recruitment / initial data collection 2006 2011
Follow-up of participants -- --
Current number of participants recruited 3000
Current number of collected DNA samples --

AVAILABLE DOCUMENTS

  Document type Availability
1 General study protocol
2 Specific protocols/procedures (data collection, samples management, etc.)
3 Questionnaires
4 Physical and cognitive measures
5 DNA processing
6 Consent forms
7 Pamphlet / project description
8 Governance / ethics documentation
9 Other

General Information

Name SCCS- Multiethnic Cohort (MEC) questionniare
Last update 07/17/2009
Version or reference year v.4, 24 Sept 2008
Phase Baseline
Year interval 2006 to --

Contact

Kee-Seng Chia (Dr.)
National University of Singapore, Dep. of Community, Occupational and Family Medicine (MD3)
Singapore 117597
Phone: +65 65164971
Email: ephcks@nus.edu.sgMail

Utilization conditions

SCCS

Methods

Legend Yes No

Respondent

  • Yes Participant
  • No Proxy

Administration environment

  • No Over the phone
  • No Hospital, clinic, university or recruitment center
  • Yes Respondent / Proxy residence

Administration mode

  • No Auto administered
  • No Auto administrated with face to face validation by trained personnel
  • Yes Administrated by trained personel / Physician

Administration format

  • Yes Paper questionnaire
  • No Computerized

Administration language

  • English
  • Malay

Documents

Available Format

  • Adapted questionnaireWeb page
  • SCCS_questionnairePDF

NOTICE: HTML document format may differ slightly from the actual questionnaire. Please refer to the original PDF document for exact reproduction.

General Information

Name SCCS- Multiethnic Cohort (MEC) questionniare
Number of Question Blocks 54

Questionnaire and Question Block List

Click on the View block to see the block of questions related to a domain or a group of domains.
Block 1 View block
  • Life Habits/Behaviours / Tobacco use
Block 2 View block
  • Physical Environment / Early life and in utero exposures / Chemical Exposures / Passive Smoke Exposure
Block 3 View block
  • Physical Environment / Environmental exposures / Chemical environmental exposures / Passive Smoke Exposure
Block 4 View block
  • Physical Environment / Occupational Exposures / Chemical Occupational Exposures / Passive Smoke Exposure
Block 5 View block
  • Life Habits/Behaviours / Alcohol use
Block 6 View block
  • Health Information / Medication Intake (ATC/DDD)
Block 7 View block
  • Health Information / Individual Disease history / Diseases of the circulatory system
Block 8 View block
  • Health Information / Individual Disease history / Diseases of the circulatory system
Block 9 View block
  • Health Information / Individual Disease history / Diseases of the circulatory system
Block 10 View block
  • Health Information / Individual Disease history / Endocrine, nutritional and metabolic diseases
Block 11 View block
  • Health Information / Individual Disease history / Diseases of the circulatory system
Block 12 View block
  • Health Information / Individual Disease history
Block 13 View block
  • Health Information / Reproductive history / Number of children
  • Sociodemographic Characteristics / Kinship
Block 14 View block
  • Health Information / Familial Disease History (ICD10*) / Diseases of the circulatory system
Block 15 View block
  • Health Information / Familial Disease History (ICD10*) / Endocrine, nutritional and metabolic diseases
Block 16 View block
  • Health Information / Familial Disease History (ICD10*) / Neoplasms
Block 17 View block
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Genitourinary System
  • Health Information / Medication Intake (ATC/DDD) / Genito urinary system and sex hormones (G)
  • Health Information / Women's health / Menstruation
Block 18 View block
  • Health Information / Individual Disease history / Pregnancy, childbirth and the puerperium
  • Health Information / Medical Health Intervention (C239) / Obstetrical and Fetal Interventions / Termination of Pregnancy
  • Health Information / Reproductive history / Parity/Gravidity
  • Health Information / Women's health / Breast feeding
Block 19 View block
  • Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency
Block 20 View block
  • Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency
  • Socioeconomic Characteristics / Working status / Subject Working status/history
Block 21 View block
  • Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency
Block 22 View block
  • Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency
Block 23 View block
  • Life Habits/Behaviours / Nutrition / Nutritional Behaviours and Perception of Nutritional Habits
Block 24 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Cereals, Bread, Starches
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Fat Intake
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Meat, Eggs, Fish and Alternatives
Block 25 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Cereals, Bread, Starches
Block 26 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Cereals, Bread, Starches
Block 27 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Cereals, Bread, Starches
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Meat, Eggs, Fish and Alternatives
Block 28 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency
Block 29 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Meat, Eggs, Fish and Alternatives
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Vegetables and Fruits
Block 30 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Fat Intake
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Salt and Food Supplement
Block 31 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Vegetables and Fruits
Block 32 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Fat Intake
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Meat, Eggs, Fish and Alternatives
Block 33 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Fat Intake
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Meat, Eggs, Fish and Alternatives
Block 34 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Meat, Eggs, Fish and Alternatives
Block 35 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Meat, Eggs, Fish and Alternatives
Block 36 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Sweets, Baked goods
Block 37 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Sweets, Baked goods
Block 38 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Beverages (other than water or alcohol)
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Cereals, Bread, Starches
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Fat Intake
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Meat, Eggs, Fish and Alternatives
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Vegetables and Fruits
Block 39 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Fat Intake
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Meat, Eggs, Fish and Alternatives
Block 40 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Milk products
Block 41 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Beverages (other than water or alcohol)
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Caffeine
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Fat Intake
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Milk products
Block 42 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Fat Intake
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Milk products
Block 43 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Meat, Eggs, Fish and Alternatives
Block 44 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Fat Intake
Block 45 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Beverages (other than water or alcohol)
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Caffeine
Block 46 View block
  • Sociodemographic Characteristics / Gender
Block 47 View block
  • Sociodemographic Characteristics / Age/Birth Date / Subject age / birth date
Block 48 View block
  • Sociodemographic Characteristics / Ethnicity/Race
Block 49 View block
  • Sociodemographic Characteristics / Residence / Residential History
Block 50 View block
  • Sociodemographic Characteristics / Household Status / Subjet Household Status
Block 51 View block
  • Socioeconomic Characteristics / Education level / Subject education level
Block 52 View block
  • Socioeconomic Characteristics / Working status / Subject Working status/history
Block 53 View block
  • Socioeconomic Characteristics / Income
Block 54 View block
  • Sociodemographic Characteristics / Age/Birth Date / Subject age / birth date
  • Sociodemographic Characteristics / Gender
  • Sociodemographic Characteristics / Residence / Current Residence

General information

Name Physical and Cognitive Measures
Last update 07/13/2009
Collected at phase Baseline
Year interval 2006 to 2011

Contact

Kee-Seng Chia (Dr.)
Centre for Molecular Epidemiology, & Department of Community, Occupational and Family Medicine (MD3),
Singapore 117597
Phone: +65 65164971
Email: ephcks@nus.edu.sgMail

Physical and cognitive measures collected

Legend Yes No

BODY STRUCTURES

ANTHROPOMETRIC STRUCTURES

Anthropometric measures

Yes Weight (kg)

Yes Height (cm)

Yes Standing height

Yes Body circumferences (cm)

Yes Waist circumference

Yes Hip circumference

BODY FUNCTIONS

SENSORY FUNCTIONS AND PAIN

Seeing and related functions

Yes Vision and related functions (Retinal photo)

FUNCTIONS OF THE CARDIOVASCULAR AND RESPIRATORY SYSTEMS

Functions of the cardiovascular system

Yes Blood pressure (mmHg)

Yes Other measures of the cardiovascular functions (Brachial-ankle blood pressure)

OTHER BODY FUNCTIONS

Other measures of the body functions

Monofilament 5.07 sensory test & Neurothesiometer reading (Mv)

Administration mode

Legend Yes No

Administration environment

Yes Hospital, clinic, university or recruitment center

No Participant residence

No Other

Staff administering test

Yes Professionals (nurses, clinicians, etc)

Yes Interviewers/research assistants

No Other

Documentation on procedures

Administration language English

Standard operating procedures (SOPs) or reference information

General Information

Name DNA Processing
Study name Singapore Consortium of Cohort Studies [SCCS]
Last update 05/13/2008

Contact

Kee-Seng Chia (Dr.)
 Singapore 117597
Phone: +65 65164971
Email: ephcks@nus.edu.sgMail

Samples

Legend Yes No
Sample name Blood
  Main laboratory National University of Singapore, Dep. of Community, Occupational and Family Medicine (MD3)
  Sample labels/traceability (% of samples)
  • No RFID radio frequency identification
  • No Barcode
  • No Printed labels
  • No Handwritten numbers
  • No Others
Pre-extraction sample storage format Substrate storage condition
  • Yes Fresh
  • No Refrigerated
  • No Frozen
  • No Dried (paper)
  • No Liquid Nitrogen
  • No Other
Substrate storage period
  • No Short term
  • No Long term
Protocols Fresh blood collected in EDTA tube, to be processed for DNA within 5 working days.
DNA extraction DNA extraction method
  • Yes Salting out
  • No Phenol-chloroform
  • No Columnary-extraction
  • Yes Magnetic beads
  • No Oragene (saliva)
  • No Others
Automation of handling
  • No Manual
  • Yes Automated
Protocols Automated DNA extraction using Gentra Autopure LS.
DNA handling and storage DNA diluent
  • Yes TE
  • No H2O
  • No Others
DNA concentration (ng/µl)
Storage conditions
  • No 4°C
  • No -20°C
  • No -40°C
  • Yes -80°C
  • No Dried
  • No Others
Protocols All DNA sample to be divided in multiple vials and kept in 2 independent freezers.
DNA quantification Methods
  • Yes A260/A280
  • Yes Picogreen
  • No Nanodrop
  • No Others
Technical quality
  • Yes Automated
  • No Manual
  • No Reproducibility
Protocols Mainly using A260/A280. Will be swtiching to Picogreen soon. Automation performed with the help of an automated liquid handler.
DNA quality control Percentage of samples that are tested 100.0
DNA quality method
  • Yes Agarose gel
  • No PCR
  • Yes A260/A280 ratio
  • Yes Others (Real-time PCR)
Protocols Agarose and A260/A280 ratio as the standard QC methods for all DNA samples. RT-PCR for sample verification if needed.

General Information

Name Information Technologies
Study name Singapore Consortium of Cohort Studies [SCCS]
Last update 11/06/2008

Contact

Cinda Ong
National University of Singapore
Singapore 138671
Phone: +65 67738969

Software

Legend Yes No

Biobanking areas covered

  • Yes Participant recruitment (ex: CATI, CRM)
  • Yes Data collection
  • Yes Questionnaires (ex: CAPI)
  • No Physical and cognitive measures
  • No Sample collection, storage and processing
  • No Collection
  • No Sample bio-repository management system (ex: sample storage management software)
  • No LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • No Data repository
  • No Data warehousing
  • No Study monitoring (ex: quality control)
  • No User data / sample request management

Name and version of programming language

ASP.NET 2.0 C#

Internal/external development

  • Yes In-house by IT department
  • No By an external company

Shareability

  • Yes Freely available
  • No Purchaseable
  • No Needs extensive work
  • No Not for share

Comments

No information available

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