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CARTaGENE [CaG] Download as PDF

GENERAL INFORMATION

Name CARTaGENE
Acronym CaG
Last update 09/22/2009

Affiliation

Principal investigators

Bartha Maria Knoppers (Dr.)
McGill University
Claude Laberge (Dr.)
Laval University
Philip Awadalla (Associate professor)
University of Montreal
Béatrice Godard (Dr.)
University of Montreal
Daniel Gaudet (Dr.)
University of Montreal
Isabel Fortier (Dr.)
University of Montreal

Contacts

Philip Awadalla (Associate professor)
Université de Montréal
Email: philip.awadalla@umontreal.caMail
Claude Laberge (Dr.)
Unité de recherche en génétique humaine, Laval University
Ste-Foy G1V 4G2
Phone: 418.654.2186
Email: claberge@crchul.ulaval.caMail

Website

Funding agencies

  • Genome Quebec
  • Ministry of Economic Development and Research
  • Genome Canada
  • Quebec Government's Ministry of Health and Social Services
  • Canadian Partnership for Tomorrow Project
  • Quebec Network for Applied Genetic Medicine of the Quebec Health Research Funds

BACKGROUND

Entirely publicly funded, CARTaGENE will be an infrastructure for population genomics research. This resource could therefore contribute to the development of better diagnosis, treatment and prevention programs for disease. CARTaGENE seeks to create a resource for the advancement of genetic research, with the aim of improving the health of Quebecers. This public resource will operate under a governance framework and will consist of a databank and a biobank. CARTaGENE will contain environmental, demographic and health data. Its biobank will contain DNA and blood and urine samples. Access to CARTaGENE will be granted to researchers who are seeking to better understand how genes interact with other genes, with the environment and with lifestyle factors.

OBJECTIVES

CARTaGENE's objectives are:
1) To help researchers understand the genetic, environmental and lifestyle factors involved in common diseases such as heart disease, diabetes and cancer. This increased understanding of the determinants of health and disease will, in the long term, translate into improved disease prevention, diagnostics and treatment, and contribute to a better allocation of health care resources;
2) To contribute to the international harmonization of research tools and methods and governance approaches for population genomics studies. This will help to increase the statistical power and reliability of all population genomics studies, and to translate the studies into health benefits faster.

Topics of interest

  • No Broad approach with no specific topic of interest
  • Yes Target specific topics of interest (health outcomes, health determinants, etc.) (Common chronic diseases. Keywords: endocrine, metabolic and nutritional diseases, diseases of the circulatory system, diseases of the respiratory system, food intolerance and allergies, neoplasms, diseases of the genitourinary tract, diseases of the musculoskeletal system and connective tissue, autoimmune diseases, diseases of the skin and subcutaneous tissue, diseases of the eyes, diseases of the nervous system and mental and behavioural disorders.)

METHODS

Legend Yes No Unknown

General design

Study design Cohort
Type of participants Individuals
Target or final number of participants 20400
Target or final number of DNA 20400

Participant selection / Characteristics of the population

Selection criteria

Yes Country of residence Canada (Province of Quebec, Montreal, Quebec, Sherbrooke, Chicoutimi (Saguenay))

Supplementary informations

People living in Indian reserves and those usually living in the following institutional collective household are excluded of the study: hospitals, long-term facilities-based care, some prisons and correctional facilities, and some other facilities such as rehabilitation centres, therapy center or drug rehabilitation centre. Also, the Short Portable Mental Status Questionnaire (SPMSQ) is used over the recruitment interview (phone) to exclude people who can’t consent.

Recruitment procedures

The research team will call upon the population of Quebec. 20,400 individuals aged 40-69 years will be randomly selected from the index of the Régie de l'assurance maladie du Québec (i.e. the Quebec health insurance system). Selected candidates may accept or refuse to participate. Since the selection process will be random, the health status of the selected candidates will vary. The sample represents 1% of this age group in the selected regions of Quebec.

Data Sources

  Cross-sectional Repeated/continuous
Yes Questionnaires to participants/respondents Yes Yes
Yes Direct physical measures Yes No
Yes Biological samples Yes No
No Medical paper
Yes Electronic databases
Yes Genealogical records  

Collection procedures

Participants will be contacted by La Régie de l’assurance maladie du Québec (RAMQ). Consenting persons will answer a questionnaire; will meet a nurse, who will take various clinical measurements, blood and urine samples. Data and samples will be gathered through largely non invasive measures (weight, height, blood pressure, bone density, etc.) and carried out in a health care facility. The required time is approximately two and a half hours (2 hrs and 30 minutes).

Follow up procedures

Regular re-contact and follow-up via governmental electronic health databases.

Baseline principal variables of interest

Health information

  • Yes Diseases history - ICD-10 All conditions
  • Yes Medication intake
  • Yes Familial disease history
  • No Early life
  • Yes Women's health
  • Yes Quality of life

Physical / Biochemical measures

Yes Body structure measures Yes Biochemical measures
Yes Body function measures  

Sociodemographic Characteristics

Yes Birth location Yes Parents birth location
Yes Ethnicity/Race Yes Gender
Yes Marital status Yes Date of birth

Socioeconomic Characteristics

Yes Education level Yes Income
Yes Working status  

Life habits / Behaviours

Yes Physical activity Yes Smoking / Tobacco Use
Yes Nutrition Yes Alcohol intake

Physical environment

Yes Passive smoking No Mobile phone use

Other variables of interest

Sleep, UV exposure, depressive symptoms, anxiety symptoms, stress at work, major life events, perceived quality of health, social support, non prescribed medication.

Sample management

Biological samples

Yes Blood No Buccal cells
No Cord blood No Tissues
No Saliva Yes Urine

Biological samples format

  Fresh Frozen Dried (paper) Other Specification
Blood No Yes Yes No

Genome-Wide Association (GWA) analyses

  • Yes Plan to proceed to GWA analyses later

GOVERNANCE

Legend Yes No

Allow access to data or samples to external researchers

Yes Data (questionnaire-derived, measured…)
Yes Biological samples

STATUS

Current status

Phase Start End
Preparation phase/Pilot 2007 2008
Recruitment / initial data collection 2009 2010
Follow-up of participants 2010 2010
Study ended   2010

Supplementary informations

During a first phase, 20,400 participants will be recruited. The first 400 will be randomly selected from the Sherbooke and Montreal metropolitan regions. These first 400 persons will allow CARTaGENE to finalize the protocols to be used for another 20,000. Recontact of the study participants will be done approximately 6 months after the baseline interview. Follow-up interviews will focus and assessment of nutritional status and environmental exposure and will not include biological sample collection.

Current number of participants recruited 218 in date of 08/01/2009

Recruitment officially lauched in 07-2009. As of Septembre 1st 2009, >1000 interviews were scheduled.

Current number of collected DNA samples 218 in date of 08/01/2009
Participation rate 20% in date of 08/01/2009

AVAILABLE DOCUMENTS

  Document type Availability
1 General study protocol catherine.boileau@cartagene.qc.caMail
2 Specific protocols/procedures (data collection, samples management, etc.) catherine.boileau@cartagene.qc.caMail
3 Questionnaires
4 Consent forms
5 Pamphlet / project description
6 Governance / ethics documentation claberge@crchul.ulaval.caMail

PUBLICATIONS AND RELEVANT DOCUMENTATION

1
Godard B, Marshall J, Laberge C Community Engagement in Genetic Research: Results of the First Public Consultation for the Quebec CARTaGENE Project. Community Genet 2007; 10:147-158 (DOI: 10.1159/000101756)


General Information

Name CARTaGENE Health Questionnaire Part 1: Identifying Questionnaire
Last update 11/05/2009
Version or reference year 2009; May 28, v1.0
Phase Phase A
Year interval 2009 to 2010
Supplementary informations Phase A is the baseline

Questionnaire owner

  • CARTaGENE - Université de Montréal

Contact

Catherine Boileau
Montreal H3V 1A2
Phone: (514) 343-7703 ext: 33496
Email: catherine.boileau@cartagene.qc.caMail

Utilization conditions

No restrictions. CARTaGENE - Université de Montréal should be stated when this questionnaire is used.

Information on validity

Validity: The content of the questionnaire has been revised and approved by over 30 experts from various scientific fields. This questionnaire is largely harmonized with other large Canadian Cohorts (The Canadian Partnership for Tomorrow Project CPTP). A significant proportion of the questions included in the self-administered questionnaire were also part of the pilot phase questionnaire. which was tested in a sample of 223 respondants (age 40-69) The self-administered questionnaire has been piloted to test for time and general comprehension in a small group of people (n=8); average time for completion of the questionnaire was 4:32 minutes.

Bias: Items concerning residential history may be subject to recall bias

Limitations: No major limitations

References

Methods

Legend Yes No

Respondent

  • Yes Participant
  • No Proxy

Administration environment

  • No Over the phone
  • Yes Hospital, clinic, university or recruitment center
  • No Respondent / Proxy residence

Administration mode

  • No Auto administered
  • No Auto administrated with face to face validation by trained personnel
  • Yes Administrated by trained personel / Physician

Administration format

  • No Paper questionnaire
  • Yes Computerized

Administration language

  • English
  • French

Documents

Available Format

NOTICE: HTML document format may differ slightly from the actual questionnaire. Please refer to the original PDF document for exact reproduction.

General Information

Name CARTaGENE Health Questionnaire Part 1: Identifying Questionnaire
Number of Question Blocks 8

Questionnaire and Question Block List

Click on the View block to see the block of questions related to a domain or a group of domains.
Block 1 View block
  • Sociodemographic Characteristics / Gender
Block 2 View block
  • Sociodemographic Characteristics / Age/Birth Date / Subject age / birth date
Block 3 View block
  • Sociodemographic Characteristics / Residence / Current Residence
  • Sociodemographic Characteristics / Residence / Residential History
Block 4 View block
  • Sociodemographic Characteristics / Birth location / Subject's birth location
Block 5 View block
  • Sociodemographic Characteristics / Residence / Residential History
Block 6 View block
  • Sociodemographic Characteristics / Birth location / Subject's family's birth location
Block 7 View block
  • Sociodemographic Characteristics / Ethnicity/Race
Block 8 View block
  • Socioeconomic Characteristics / Working status / Subject Working status/history

General Information

Name CARTaGENE Health Questionnaire Part 2: Self-Administered Questionnaire
Last update 11/05/2009
Version or reference year 2009, May 28, v1.0
Phase Phase A
Year interval 2009 to 2010
Supplementary informations Phase A is the baseline

Questionnaire owner

  • CARTaGENE, Université de Montréal

Contact

Catherine Boileau
CARTaGENE
Montreal H3V 1A2
Phone: (514) 343-7703 ext: 33496
Email: catherine.boileau@cartagene.qc.caMail

Utilization conditions

No restrictions. CARTaGENE - Université de Montréal should be stated when this questionnaire is used.

Information on validity

Validity: The content of the questionnaire has been revised and approved by over 30 experts from various scientific fields. This questionnaire is largely harmonized with other large Canadian Cohorts (The Canadian Partnership for Tomorrow Project CPTP). A significant proportion of the questions included in the self-administered questionnaire were also part of the pilot phase questionnaire. which was tested in a sample of 223 respondants (age 40-69) The self-administered questionnaire has been piloted to test for time and general comprehension in a small group of people (n=8); average time for completion of the questionnaire was 29 minutes.
Scales that are included in this questionnaire have previously been validated and extensively used in different contexts, these include Patient Health Questionnaire (PHQ-9), General Anxiety Scale (GAD-7), Job Content Questionnaire (JCC), International PHysical Activity Questionnaire (IPAQ) (references are provided below).

Bias: The touch-screen application has been developped for use in the general population, including those individuals who are not familiar with computers. However, more testing is required to evaluate the degree to which the mode of administration may lead to response bias.

Limitations: The questionnaire is limited to people who can read and have not visual impairment.

References

Methods

Legend Yes No

Respondent

  • Yes Participant
  • No Proxy

Administration environment

  • No Over the phone
  • Yes Hospital, clinic, university or recruitment center
  • No Respondent / Proxy residence

Administration mode

  • Yes Auto administered
  • No Auto administrated with face to face validation by trained personnel
  • No Administrated by trained personel / Physician

Administration format

  • No Paper questionnaire
  • Yes Computerized

Administration language

  • English
  • French

Documents

Available Format

NOTICE: HTML document format may differ slightly from the actual questionnaire. Please refer to the original PDF document for exact reproduction.

General Information

Name CARTaGENE Health Questionnaire Part 2: Self-Administered Questionnaire
Number of Question Blocks 25

Questionnaire and Question Block List

Click on the View block to see the block of questions related to a domain or a group of domains.
Block 1 View block
  • Sociodemographic Characteristics / Household Status / Subjet Household Status
Block 2 View block
  • Sociodemographic Characteristics / Household Status / Structure of the Household
Block 3 View block
  • Sociodemographic Characteristics / Kinship
Block 4 View block
  • Sociodemographic Characteristics / Language
Block 5 View block
  • Socioeconomic Characteristics / Education level / Subject education level
Block 6 View block
  • Socioeconomic Characteristics / Income
Block 7 View block
  • Socioeconomic Characteristics / Working status / Subject Working status/history
Block 8 View block
  • Life Habits/Behaviours / Tobacco use
Block 9 View block
  • Physical Environment / Environmental exposures / Chemical environmental exposures / Passive Smoke Exposure
  • Physical Environment / Occupational Exposures / Chemical Occupational Exposures / Passive Smoke Exposure
Block 10 View block
  • Life Habits/Behaviours / Alcohol use
Block 11 View block
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Beverages (other than water or alcohol)
  • Life Habits/Behaviours / Nutrition / Food intake and Frequency / Vegetables and Fruits
Block 12 View block
  • Life Habits/Behaviours / Sleep Behaviours
Block 13 View block
  • Body structures / Hair
Block 14 View block
  • Body structures / Skin
  • Physical Environment / Environmental exposures / Physical environmental exposures / Radiation (ionizing and non ionizing)
Block 15 View block
  • Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency
  • Socioeconomic Characteristics / Working status / Subject Working status/history
Block 17 View block
  • Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency
  • Life Habits/Behaviours / Travel History and Habits
Block 19 View block
  • Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency
Block 20 View block
  • Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency
Block 21 View block
  • Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency
Block 22 View block
  • Health Information / Perception of health/quality of life
Block 23 View block
  • Health Information / Perception of health/quality of life
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / General symptoms and signs
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving cognition, perception, emotional state and behaviour
Block 24 View block
  • Health Information / Perception of health/quality of life
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / General symptoms and signs
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving cognition, perception, emotional state and behaviour
Block 25 View block
  • Health Information / Perception of health/quality of life
  • Social Environment / Working Social Environment
Block 26 View block
  • Health Information / Perception of health/quality of life
  • Social Environment / Familial and social environment
Block 27 View block
  • Health Information / Perception of health/quality of life
  • Social Environment / Familial and social environment

General Information

Name CARTaGENE Health Questionnaire Part 3: Assisted Questionnaire
Last update 11/05/2009
Version or reference year 2009, May 28, v1.0
Phase Phase A
Year interval 2009 to 2010
Supplementary informations Phase A is the baseline

Questionnaire owner

  • CARTaGENE - Université de Montréal

Contact

Catherine Boileau
CARTaGENE
Montreal H3V 1A2
Phone: (514) 343-7703 ext: 33496
Email: catherine.boileau@cartagene.qc.caMail

Utilization conditions

No restrictions . CARTaGENE - Université de Montréal should be stated when this questionnaire is used.

Information on validity

Validity: The content of the questionnaire has been revised and approved by over 30 experts from various scientific fields. This questionnaire is largely harmonized with questionnaires used by other large Canadian Cohorts (The Canadian Partnership for Tomorrow Project CPTP). A significant proportion of the questions included in the self-administered questionnaire were also part of the pilot phase questionnaire. which was tested in a sample of 223 respondants (age 40-69) This interviewer assisted questionnaire has been piloted to test for time and general comprehension in a small group of people (n=8); average time for completion of the questionnaire was 19 minutes. Question items that are included in the questionnaire come from various validated sources:
1. Canadian Health Measures Survey
2. National Health and Nutrition Examination Survey (NHANES)
3. Ontario Chronic Disease Study
4. The International Organization for Standardization codes (ISO- 3166)
5. The Tomorrow Project
6. UK Biobank

Bias: Questions included in the questionnaire require that respondants remember details about their and their family's general health - some items may be subject to recall bias

Limitations: No major limitations.

References

Methods

Legend Yes No

Respondent

  • Yes Participant
  • No Proxy

Administration environment

  • No Over the phone
  • Yes Hospital, clinic, university or recruitment center
  • No Respondent / Proxy residence

Administration mode

  • No Auto administered
  • No Auto administrated with face to face validation by trained personnel
  • Yes Administrated by trained personel / Physician

Administration format

  • No Paper questionnaire
  • Yes Computerized

Administration language

  • English
  • French

Documents

Available Format

NOTICE: HTML document format may differ slightly from the actual questionnaire. Please refer to the original PDF document for exact reproduction.

General Information

Name CARTaGENE Health Questionnaire Part 3: Assisted Questionnaire
Number of Question Blocks 48

Questionnaire and Question Block List

Click on the View block to see the block of questions related to a domain or a group of domains.
Block 1 View block
  • Health Information / Individual Disease history / Endocrine, nutritional and metabolic diseases
  • Health Information / Individual Disease history / Pregnancy, childbirth and the puerperium
  • Health Information / Medication Intake (ATC/DDD) / Alimentary tract and metabolism (A)
Block 2 View block
  • Health Information / Individual Disease history / Endocrine, nutritional and metabolic diseases
Block 3 View block
  • Health Information / Individual Disease history / Endocrine, nutritional and metabolic diseases
  • Health Information / Medical Health Intervention (C239) / Clinical Laboratory Interventions
Block 4 View block
  • Health Information / Individual Disease history / Diseases of the circulatory system
Block 6 View block
  • Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving the circulatory and respiratory systems
Block 7 View block
  • Health Information / Individual Disease history / Diseases of the circulatory system
Block 9 View block
  • Health Information / Individual Disease history / Diseases of the respiratory system
Block 12 View block
  • Health Information / Individual Disease history / Injury, poisoning and certain other consequences of external causes
Block 13 View block
  • Health Information / Individual Disease history / Neoplasms
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions
  • Health Information / Medication Intake (ATC/DDD) / Antineoplastic and immunomodulating agents (L)
Block 14 View block
  • Health Information / Individual Disease history / Diseases of the digestive system
Block 15 View block
  • Health Information / Individual Disease history / Certain infectious and parasitic diseases
  • Health Information / Individual Disease history / Diseases of the digestive system
Block 16 View block
  • Health Information / Individual Disease history / Diseases of the digestive system
Block 17 View block
  • Health Information / Individual Disease history / Diseases of the genitourinary system
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Genitourinary System
Block 18 View block
  • Health Information / Individual Disease history / Diseases of the musculoskeletal system and connective tissue
Block 20 View block
  • Health Information / Individual Disease history / Diseases of the musculoskeletal system and connective tissue
Block 21 View block
  • Health Information / Individual Disease history / Diseases of the skin and subcutaneous tissue
Block 22 View block
  • Health Information / Individual Disease history / Diseases of the eye and adnexa
Block 23 View block
  • Health Information / Individual Disease history / Diseases of the nervous system
Block 24 View block
  • Health Information / Individual Disease history / Mental and behavioural disorders
Block 26 View block
  • Health Information / Individual Disease history / Diseases of the musculoskeletal system and connective tissue
  • Health Information / Individual Disease history / Injury, poisoning and certain other consequences of external causes
Block 27 View block
  • Health Information / Individual Disease history
Block 28 View block
  • Body structures / Anthropometric structures / Anthropometric measures / Weight
  • Health Information / Perception of health/quality of life
Block 29 View block
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions
Block 30 View block
  • Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Genitourinary System
Block 31 View block
  • Health Information / Medical Health Intervention (C239) / Diagnostic Imaging Interventions / Diagnostic Imaging Interventions on the Skin, Subcutaneous Tissue, and Breast
Block 32 View block
  • Health Information / Medical Health Intervention (C239) / Clinical Laboratory Interventions
  • Health Information / Medical Health Intervention (C239) / Diagnostic Interventions / Diagnostic Interventions on the Genitourinary System
Block 33 View block
  • Health Information / Medical Health Intervention (C239) / Clinical Laboratory Interventions
  • Health Information / Medical Health Intervention (C239) / Diagnostic Interventions / Diagnostic Interventions on the Genitourinary System
Block 34 View block
  • Health Information / Medical Health Intervention (C239) / Clinical Laboratory Interventions
  • Health Information / Medical Health Intervention (C239) / Diagnostic Interventions / Diagnostic Interventions on the Digestive and Hepatobiliary Tract
Block 35 View block
  • Health Information / Medical Health Intervention (C239) / Diagnostic Imaging Interventions / Diagnostic Imaging Interventions on the Digestive and Hepatobiliary Tract
Block 36 View block
  • Health Information / Medical Health Intervention (C239) / Other Healthcare Interventions
Block 37 View block
  • Health Information / Medical Health Intervention (C239)
Block 38 View block
  • Health Information / Medication Intake (ATC/DDD)
Block 39 View block
  • Health Information / Women's health / Menstruation
Block 40 View block
  • Health Information / Medication Intake (ATC/DDD) / Genito urinary system and sex hormones (G)
Block 41 View block
  • Health Information / Reproductive history / Number of children
  • Health Information / Reproductive history / Parity/Gravidity
Block 42 View block
  • Health Information / Women's health / Breast feeding
Block 43 View block
  • Health Information / Individual Disease history / Diseases of the genitourinary system
  • Health Information / Medication Intake (ATC/DDD) / Genito urinary system and sex hormones (G)
Block 44 View block
  • Health Information / Women's health / Menopause
Block 45 View block
  • Health Information / Medication Intake (ATC/DDD) / Genito urinary system and sex hormones (G)
Block 46 View block
  • Health Information / Reproductive history / Number of children
Block 47 View block
  • Health Information / Familial Disease History (ICD10*)
Block 48 View block
  • Health Information / Familial Disease History (ICD10*) / Diseases of the circulatory system
Block 51 View block
  • Health Information / Familial Disease History (ICD10*) / Endocrine, nutritional and metabolic diseases
Block 52 View block
  • Health Information / Familial Disease History (ICD10*) / Diseases of the respiratory system
Block 53 View block
  • Health Information / Familial Disease History (ICD10*) / Diseases of the digestive system
  • Health Information / Familial Disease History (ICD10*) / Diseases of the respiratory system
  • Health Information / Familial Disease History (ICD10*) / Mental and behavioural disorders
Block 54 View block
  • Health Information / Familial Disease History (ICD10*)
Block 55 View block
  • Social Environment / Familial and social environment
Block 56 View block
  • Health Information / Familial Disease History (ICD10*) / Neoplasms

General information

Name Physical and cognitive measures
Last update 09/17/2009
Collected at phase Phase A (baseline)
Year interval 2009 to 2010

Contacts

Catherine Boileau
CARTaGENE
Montreal H3V 1A2
Phone: (514) 343-7703 ext: 33496
Email: catherine.boileau@cartagene.qc.caMail

Physical and cognitive measures collected

Legend Yes No

BODY STRUCTURES

ANTHROPOMETRIC STRUCTURES

Anthropometric measures

Yes Weight (one measurement)

Yes Height (2-3 measurements)

Yes Standing height

Yes Sitting height

Yes Body circumferences (2-3 measurements)

Yes Waist circumference

Yes Hip circumference

Yes Other (Arm length.)

Body composition

Yes Bioimpedance (Leg-to-leg impedance.)

Yes Bone density (Heel ultrasound bone density, one measurement)

BODY FUNCTIONS

MENTAL FUNCTIONS

Global mental functions

Yes Cognitive functions (working memory and executive function)

Specific mental functions

Yes Memory functions (Paired associate learning test)

Yes Other specific mental functions (Verbal and numerical problem solving)

FUNCTIONS OF THE CARDIOVASCULAR AND RESPIRATORY SYSTEMS

Functions of the cardiovascular system

Yes Blood pressure (3 readings at intervals of 2 minutes)

Yes Heart rate (Measured by blood pressure, arteriel stiffness, and ECG devices)

Yes Heart rate at rest

Yes Electrical activity (4 limb electrodes that produce 3 standard limb and 3 augment leads)

Yes Other measures of the cardiovascular functions (Arteriel stiffness, central aortic blood pressure)

Functions of the respiratory system

Yes Respiratory functions (The basic forced volume vital capacity (FVC) test, 2-5 measurements)

NEUROMUSCULOSKELETAL AND MOVEMENT-RELATED FUNCTIONS

Yes Reaction Time

Yes Grip strength (Duplicate, once for participants suffering from myotonia)

HANDEDNESS / LATERALITY

Yes Handedness functions

Administration mode

Legend Yes No

Administration environment

Yes Hospital, clinic, university or recruitment center

No Participant residence

No Other

Staff administering test

Yes Professionals (nurses, clinicians, etc)

Yes Interviewers/research assistants

No Other

Documentation on procedures

Administration language French

Utilization conditions

Intellectual property requirements: All SOPs are available upon request (catherine.boileau@cartagene.qc.ca). CARTaGENE - Université de Montréal should be stated as the author of these SOPs.

Safety and scientific restrictions: counter-indications and factors that may bias the outcome of the tests are clearly stated in the documents.
No ethical or legal restrictions apply.

General Information

Name DNA Processing
Study name CARTaGENE [CaG]
Last update 09/22/2009

Contact

Steve Arsenault
 Genome Quebec - Centre hospitalier affilié universitaire régional de Chicoutimi Biobank
Chicoutimi
Phone: 418.541.1234 x2821
Email: sarsenault@genomequebec.comMail

Samples

Legend Yes No
Sample name Blood Saliva
  Main laboratory GQ-CAUR de Chicoutimi BIobank]
  Sample labels/traceability (% of samples)
  • No RFID radio frequency identification
  • Yes Barcode (1D)
  • Yes Printed labels
  • No Handwritten numbers
  • No Others
  • No RFID radio frequency identification
  • Yes Barcode (1D)
  • Yes Printed labels
  • No Handwritten numbers
  • No Others
Pre-extraction sample storage format Substrate storage condition
  • No Fresh
  • No Refrigerated
  • Yes Frozen (-78.5°C)
  • No Dried (paper)
  • No Liquid Nitrogen
  • No Other
  • No Fresh
  • No Refrigerated
  • Yes Frozen (-78.5°C)
  • No Dried (paper)
  • No Liquid Nitrogen
  • No Other
Substrate storage period
  • Yes Short term
  • No Long term
  • Yes Short term
  • No Long term
Laboratory in charge CARTaGENE collection sites CARTaGENE collection sites
DNA extraction DNA extraction method
  • No Salting out
  • No Phenol-chloroform
  • No Columnary-extraction
  • Yes Magnetic beads
  • No Oragene (saliva)
  • Yes Others GeneVault GeneSolve
  • No Salting out
  • No Phenol-chloroform
  • No Columnary-extraction
  • Yes Magnetic beads
  • Yes Oragene (saliva)
  • Yes Others GeneVault GeneSolve
Automation of handling
  • No Manual
  • Yes Automated
  • Yes Manual
  • Yes Automated
DNA handling and storage DNA diluent
  • Yes TE
  • Yes H2O
  • No Others
  • Yes TE
  • Yes H2O
  • No Others
DNA concentration (ng/µl)
Storage conditions
  • No 4°C
  • No -20°C
  • No -40°C
  • No -80°C
  • Yes Dried (< 50 years)
  • No Others
  • No 4°C
  • No -20°C
  • No -40°C
  • No -80°C
  • Yes Dried (< 50 years)
  • No Others
Protocols DNA Concentration: 1-60ng/µl
DNA quantification Methods
  • No A260/A280
  • Yes Picogreen
  • No Nanodrop
  • No Others
  • No A260/A280
  • Yes Picogreen
  • No Nanodrop
  • No Others
Technical quality
  • Yes Automated
  • No Manual
  • Yes Reproducibility
  • Yes Automated
  • No Manual
  • Yes Reproducibility
DNA quality control Percentage of samples that are tested
DNA quality method
  • Yes Agarose gel
  • Yes PCR
  • Yes A260/A280 ratio
  • No Others
  • Yes Agarose gel
  • Yes PCR
  • Yes A260/A280 ratio
  • No Others
Protocols Percentage of samples that are tested: <1% Percentage of samples that are tested : <1%

General Information

Name Information Technologies
Study name CARTaGENE [CaG]
Last update 09/17/2009

Contact

Serge Mani
CARTaGENE, Université de Montréal
Montreal
Phone: (1) 514-343-7703 #3919
Email: serge.mani@cartagene.qc.caMail

Software

Legend Yes No

Software overview

Biobanking areas covered CAGET OBiBa Onyx GERT OBiBa Opal CONF
Participant recruitment (ex: CATI, CRM) Yes Yes
Data collection Yes
Sample collection, storage and processing Yes Yes
Data repository Yes
Other Yes Yes
 
Programming language CAGET OBiBa Onyx GERT OBiBa Opal CONF
Name and version of programming language PL/SQL, ORACLE Java Java Java PHP/MySQL
 
Internal/external development CAGET OBiBa Onyx GERT OBiBa Opal CONF
In-house by IT department Yes Yes
By an external company Yes Yes Yes
 
Shareability CAGET OBiBa Onyx GERT OBiBa Opal CONF
Freely available Yes Yes Yes
Purchaseable
Needs extensive work Yes
Not for share Yes Yes

Software details

Biobanking areas covered

  • Yes Participant recruitment (ex: CATI, CRM)
  • No Data collection
  • No Questionnaires (ex: CAPI)
  • No Physical and cognitive measures
  • No Sample collection, storage and processing
  • No Collection
  • No Sample bio-repository management system (ex: sample storage management software)
  • No LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • No Data repository
  • No Data warehousing
  • No Study monitoring (ex: quality control)
  • No User data / sample request management

Name and version of programming language

PL/SQL, ORACLE

Internal/external development

  • Yes In-house by IT department
  • No By an external company

Shareability

  • No Freely available
  • No Purchaseable
  • No Needs extensive work
  • Yes Not for share

Biobanking areas covered

  • No Participant recruitment (ex: CATI, CRM)
  • Yes Data collection
  • Yes Questionnaires (ex: CAPI)
  • Yes Physical and cognitive measures
  • Yes Sample collection, storage and processing
  • Yes Collection
  • No Sample bio-repository management system (ex: sample storage management software)
  • No LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • No Data repository
  • No Data warehousing
  • No Study monitoring (ex: quality control)
  • No User data / sample request management
  • Yes Other (Electronic consent)

Name and version of programming language

Java

Internal/external development

  • No In-house by IT department
  • Yes By an external company (OBiBa)

Shareability

  • Yes Freely available
  • No Purchaseable
  • No Needs extensive work
  • No Not for share

Biobanking areas covered

  • No Participant recruitment (ex: CATI, CRM)
  • No Data collection
  • No Questionnaires (ex: CAPI)
  • No Physical and cognitive measures
  • Yes Sample collection, storage and processing
  • No Collection
  • Yes Sample bio-repository management system (ex: sample storage management software)
  • No LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • No Data repository
  • No Data warehousing
  • No Study monitoring (ex: quality control)
  • No User data / sample request management

Name and version of programming language

Java

Internal/external development

  • No In-house by IT department
  • Yes By an external company (OBiBa)

Shareability

  • Yes Freely available
  • No Purchaseable
  • Yes Needs extensive work
  • No Not for share

Biobanking areas covered

  • No Participant recruitment (ex: CATI, CRM)
  • No Data collection
  • No Questionnaires (ex: CAPI)
  • No Physical and cognitive measures
  • No Sample collection, storage and processing
  • No Collection
  • No Sample bio-repository management system (ex: sample storage management software)
  • No LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • Yes Data repository
  • Yes Data warehousing
  • No Study monitoring (ex: quality control)
  • Yes User data / sample request management

Name and version of programming language

Java

Internal/external development

  • No In-house by IT department
  • Yes By an external company (OBiBa)

Shareability

  • Yes Freely available
  • No Purchaseable
  • No Needs extensive work
  • No Not for share

Biobanking areas covered

  • Yes Participant recruitment (ex: CATI, CRM)
  • No Data collection
  • No Questionnaires (ex: CAPI)
  • No Physical and cognitive measures
  • No Sample collection, storage and processing
  • No Collection
  • No Sample bio-repository management system (ex: sample storage management software)
  • No LIMS (ex: biochemical analysis, DNA extraction, genotyping)
  • No Data repository
  • No Data warehousing
  • No Study monitoring (ex: quality control)
  • No User data / sample request management
  • Yes Other (Confirmation of appointments)

Name and version of programming language

PHP/MySQL

Internal/external development

  • Yes In-house by IT department
  • No By an external company

Shareability

  • No Freely available
  • No Purchaseable
  • No Needs extensive work
  • Yes Not for share

Comments

No information available

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