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Cohort of Swedish Men [COSM]

Study
Questionnaire

GENERAL INFORMATION

Name	Cohort of Swedish Men
Acronym	COSM
Last update	01/21/2010

Affiliation

Biobanking and Biomolecular Resources Research Infrastructure [BBMRI]

Principal investigator

Alicja Wolk (Prof)

Karolinska Institutet, Stockholm, Sweden

Contacts

Alicja Wolk (Professor)	Karolinska Institutet Stockholm 171 77 Phone: +46 8 5248 6170 Email: Alicja.Wolk@ki.se
Niclas Hakansson (PhD)	Karolinska Institutet Sweden Phone: +46 8 5248 7080 Email: Niclas.Hakansson@ki.se

Website

http://ki.se/ki/jsp/polopoly.jsp?d=22104&l=en

Funding agency

	Percentage	Category
Swedish Research Council - government	--	--
Swedish Cancer Society	--	--

BACKGROUND

The Cohort of Swedish Men (COSM) including about 50,000 men, born 1918-52 and living in Västmanland and Örebro Counties was established in 1997.

OBJECTIVES

To investigate the impact of gene-environment/life style factors (particularly nutritional factors) interactions on chronic diseases such as cancer, cardio-vascular diseases, osteoporosis, cataracts, obesity etc.

METHODS

	Legend Yes No Unknown

General design

Study design	Cohort
Type of participants	Individuals
Target or final number of participants	100303
Target or final number of DNA	40890

Participant selection / Characteristics of the population

Selection criteria

Gender	Men
Age	Minimun: 45 years Maximun: 79 years
Country of residence	Sweden (In Västmanland and Örebro Counties)

Recruitment procedures

All men aged 45-79 years living in two counties in central Sweden (Västmanland and Örebro) were invited to the study.

Data Sources

	Cross-sectional	Repeated/continuous
Questionnaires to participants/respondents
Direct physical measures
Biological samples
Medical paper
Electronic databases
Genealogical records

Collection procedures

During one week (Sept 1997) 100,000 questionnaires were sent by mail and answers were optically read (under a person's supervision to read unclear answers which computer could not interpret). Participants were asked to report their level of activity at work, anthropometry and nutrition habits.

Follow up procedures

After ten years (late 2007) a new questionnaire will be sent out.

Baseline principal variables of interest

Health information

Diseases history - ICD-10
- Cancer
- Asthma
- Myocardial infarction
- Stroke
- High blood pressure
- Diabetes
- Arthritis
Familial disease history
Early life
Women's health
Quality of life

Physical / Biochemical measures

Body structure measures	Biochemical measures
Body function measures

Sociodemographic Characteristics

Birth location	Parents birth location
Ethnicity/Race	Gender
Marital status	Date of birth

Socioeconomic Characteristics

Education level	Income
Working status

Life habits / Behaviours

Physical activity	Smoking / Tobacco Use
Nutrition	Alcohol intake

Physical environment

Passive smoking

Mobile phone use

Sample management

Biological samples

Blood	Buccal cells
Cord blood	Tissues
Saliva	Urine

Biological samples format

	Fresh	Frozen	Dried (paper)	Other	Specification
Buccal cells

Genome-Wide Association (GWA) analyses

Plan to proceed to GWA analyses later

GOVERNANCE

	Legend Yes No

Allow access to data or samples to external researchers

Data (questionnaire-derived, measured…)
Biological samples

STATUS

Current status

Phase	Start	End
Preparation phase/Pilot	--	--
Recruitment / initial data collection	1997	1998
Follow-up of participants	1997	--

Supplementary informations

Saliva samples/DNA: pilot 2004, study 2005-07.

Current number of participants recruited	45906 in date of 01/01/2010

Current number of collected DNA samples	31162 in date of 01/01/2010

AVAILABLE DOCUMENTS

	Document type	Availability
1	General study protocol	niclas.hakansson@ki.se
2	Specific protocols/procedures (data collection, samples management, etc.)	niclas.hakansson@ki.se
3	Questionnaires	niclas.hakansson@ki.se
4	Physical and cognitive measures
5	DNA processing
6	Consent forms	niclas.hakansson@ki.se
7	Pamphlet / project description
8	Governance / ethics documentation	niclas.hakansson@ki.se
9	Other

Detail
Question Block Annotation

General Information

Name	COSM 1997
Last update	03/11/2010
Version or reference year	1997
Phase	Baseline

Questionnaire owner

Alicja Wolk

Contact

Alicja Wolk (Professor)

Karolinska Institutet
Stockholm 171 77
Phone: +46 8 5248 6170
Email: Alicja.Wolk@ki.se

Utilization conditions

No restrictions, but Professor Alicja Wolk has to be contacted and informed about use.

Information on validity

Questionnaire is validated. For unpublished information, please contact Professor Alicja Wolk.

References

Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue - http://www.ajcn.org/cgi/content/abstract/70/1/21
Reproducibility and validity of dietary glycemic index, dietary glycemic load, and total carbohydrate intake in 141 Swedish men - http://www.ncbi.nlm.nih.gov/pubmed/17284756?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3
The validity and reproducibility of food-frequency questionnaire-based total antioxidant capacity estimates in Swedish women - http://www.ncbi.nlm.nih.gov/pubmed/18469246?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2
The validity of questionnaire-based micronutrient intake estimates is increased by including dietary supplement use in Swedish men - http://www.ncbi.nlm.nih.gov/pubmed/15226472?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=6

Methods

	Legend Yes No

Respondent

Participant
Proxy

Administration environment

Over the phone
Hospital, clinic, university or recruitment center
Respondent / Proxy residence

Administration mode

Auto administered
Auto administrated with face to face validation by trained personnel
Administrated by trained personel / Physician
Other (By mail)

Administration format

Paper questionnaire
Computerized

Administration language

English
Swedish

Documents

Available Format

NOTICE: HTML document format may differ slightly from the actual questionnaire. Please refer to the original PDF document for exact reproduction.

Comment

Questionnaires used in the COSM (the english version is not yet available on the web):
1997 http://ki.se/content/1/c6/05/39/00/COSM1997.pdf
2008 http://ki.se/content/1/c6/05/39/00/COSM2008.pdf
2009 http://ki.se/content/1/c6/05/39/00/COSM2009.pdf

The COSM 1997 questionnaire is very similar to the SMC 1997 questionnaire

General Information

Name	COSM 1997
Number of Question Blocks	27

Questionnaire and Question Block List

Click on the

to see the block of questions related to a domain or a group of domains.

Block 1

Health Information / Participants Early Life Conditions / Participant's Birth weight

Block 2

Health Information / Participants Early Life Conditions / Participant's Pregnancy duration

Block 3

Sociodemographic Characteristics / Kinship

Block 4

Body structures / Anthropometric structures / Anthropometric measures / Height

Block 5

Body structures / Anthropometric structures / Anthropometric measures / Weight

Block 6

Body structures / Anthropometric structures

Block 7

Body structures / Anthropometric structures / Anthropometric measures / Weight
Life Habits/Behaviours / Weight related behaviours

Block 9

Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency

Block 10

Life Habits/Behaviours / Alcohol use
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Beverages (other than water or alcohol)
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Caffeine
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Cereals, Bread, Starches
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Fat Intake
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Milk products
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Salt and Food Supplement

Block 11

Life Habits/Behaviours / Nutrition / Food intake and Frequency / Cereals, Bread, Starches
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Fat Intake

Block 13

Life Habits/Behaviours / Nutrition / Food intake and Frequency / Beverages (other than water or alcohol)
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Cereals, Bread, Starches
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Meat, Eggs, Fish and Alternatives
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Milk products
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Sweets, Baked goods
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Vegetables and Fruits

Block 14

Life Habits/Behaviours / Nutrition / Food intake and Frequency / Fat Intake
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Meat, Eggs, Fish and Alternatives

Block 16

Life Habits/Behaviours / Alcohol use

Block 17

Health Information / Medication Intake (ATC/DDD) / Alimentary tract and metabolism (A)
Health Information / Medication Intake (ATC/DDD) / Antiinfectives for systemic use (J)
Health Information / Medication Intake (ATC/DDD) / Blood and blood forming organs (B)
Health Information / Medication Intake (ATC/DDD) / Cardiovascular system (C)
Health Information / Medication Intake (ATC/DDD) / Dermatologicals (D)
Health Information / Medication Intake (ATC/DDD) / Genito urinary system and sex hormones (G)
Health Information / Medication Intake (ATC/DDD) / Musculo-skeletal system (M)
Health Information / Medication Intake (ATC/DDD) / Systemic hormonal preparations, excl. Sex hormones and insulins (H)
Health Information / Medication Intake (ATC/DDD) / Various
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Salt and Food Supplement

Block 18

Health Information / Medication Intake (ATC/DDD) / Alimentary tract and metabolism (A)
Health Information / Medication Intake (ATC/DDD) / Blood and blood forming organs (B)
Health Information / Medication Intake (ATC/DDD) / Cardiovascular system (C)
Health Information / Medication Intake (ATC/DDD) / Dermatologicals (D)
Health Information / Medication Intake (ATC/DDD) / Genito urinary system and sex hormones (G)
Health Information / Medication Intake (ATC/DDD) / Nervous system (N)
Health Information / Medication Intake (ATC/DDD) / Respiratory system (R)
Health Information / Medication Intake (ATC/DDD) / Sensory organs (S)
Health Information / Medication Intake (ATC/DDD) / Systemic hormonal preparations, excl. Sex hormones and insulins (H)
Health Information / Medication Intake (ATC/DDD) / Various
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Salt and Food Supplement

Block 19

Health Information / Perception of health/quality of life

Block 20

Health Information / Individual Disease history / Diseases of the circulatory system
Health Information / Individual Disease history / Diseases of the digestive system
Health Information / Individual Disease history / Diseases of the eye and adnexa
Health Information / Individual Disease history / Diseases of the genitourinary system
Health Information / Individual Disease history / Endocrine, nutritional and metabolic diseases
Health Information / Individual Disease history / Injury, poisoning and certain other consequences of external causes

Block 21

Health Information / Familial Disease History (ICD10*) / Diseases of the circulatory system
Health Information / Familial Disease History (ICD10*) / Neoplasms

Block 22

Health Information / Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified / Symptoms and signs involving the urinary system

Block 23

Health Information / Medication Intake (ATC/DDD) / Alimentary tract and metabolism (A)
Health Information / Medication Intake (ATC/DDD) / Blood and blood forming organs (B)
Health Information / Medication Intake (ATC/DDD) / Cardiovascular system (C)
Health Information / Medication Intake (ATC/DDD) / Dermatologicals (D)
Health Information / Medication Intake (ATC/DDD) / Musculo-skeletal system (M)
Health Information / Medication Intake (ATC/DDD) / Nervous system (N)
Health Information / Medication Intake (ATC/DDD) / Respiratory system (R)
Health Information / Medication Intake (ATC/DDD) / Sensory organs (S)
Health Information / Medication Intake (ATC/DDD) / Systemic hormonal preparations, excl. Sex hormones and insulins (H)

Block 24

Health Information / Medication Intake (ATC/DDD) / Cardiovascular system (C)
Health Information / Medication Intake (ATC/DDD) / Dermatologicals (D)
Health Information / Medication Intake (ATC/DDD) / Genito urinary system and sex hormones (G)

Block 25