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Sweden Mammography Cohort [SMC]

Study
Questionnaire

GENERAL INFORMATION

Name	Sweden Mammography Cohort
Acronym	SMC
Last update	01/26/2010

Affiliation

Biobanking and Biomolecular Resources Research Infrastructure [BBMRI]

Principal investigator

Alicja Wolk (Professor)

Karolinska Institutet

Contacts

Alicja Wolk (Professor)	Karolinska Institutet Stockholm 171 77 Phone: +46 8 5248 6170 Email: Alicja.Wolk@ki.se
Niclas Hakansson (PhD)	Karolinska Institutet Sweden Phone: +46 8 5248 7080 Email: Niclas.Hakansson@ki.se

Website

http://www.imm.ki.se/smc/

Funding agency

	Percentage	Category
Swedish Research Council - government	--	--
Swedish Research Council	--	Government

BACKGROUND

From 1987 to 1990, all women who lived in the Uppsala County of central Sweden and were born between 1914-1948 and all women who lived in the adjacent Västmanland County and were born between 1917-1948 received an invitation by mail to participate in a mammography screening program. A total of 66,651 women returned a completed questionnaire on diet, weight, height, parity, and education. In 1997, a follow-up questionnaire was sent to all cohort members who were still living in the study area; the follow-up questionnaire was extended to include information on physical activity, medical history, age at menarche, history of oral contraceptive use, age at menopause, postmenopausal hormone use, and lifestyle factors such as, cigarette smoking history, and use of dietary supplements.

OBJECTIVES

The general aim of the Swedish Mammography Cohort is to assess relationships between a number of modifiable factors (diet, vitamin supplement use, physical activity, smoking, alcohol, body weight, other anthropometric measures etc) and the occurrence of several major chronic diseases. We are examining associations of environmental/modifiable risk factors with several cancer sites (e.g., breast, colon, rectum, endometrium, ovary, and renal cell cancer), myocardial infarction, stroke, osteoporosis, cataracts, as well as death causes.

Topics of interest

Broad approach with no specific topic of interest
Target specific topics of interest (health outcomes, health determinants, etc.)

Topics	ICD-10 classification
Neoplasms (C00-D48)
Endocrine, nutritional and metabolic diseases (E00-E90)	E65-E68
Diseases of the eye and adnexa (H00-H59)	H25-H26
Diseases of the circulatory system (I00-I99)
Diseases of the digestive system (K00-K93)	K57
Diseases of the musculoskeletal system and connective tissue (M00-M99)	M80-M81
Diseases of the genitourinary system (N00-N99)	LUTS
Other topics	Overall mortality

METHODS

	Legend Yes No Unknown

General design

Study design	Cohort
Type of participants	Individuals
Target or final number of participants	90303
Target or final number of DNA	48910

Participant selection / Characteristics of the population

Selection criteria

Gender	Women
Age	Minimun: 39 years Maximun: 73 years
Country of residence	Sweden (Uppsala and Västmanland Counties)
Health status / clinical criteria (Cancer free)

Recruitment procedures

Data Sources

	Cross-sectional	Repeated/continuous
Questionnaires to participants/respondents
Direct physical measures
Biological samples
Medical paper
Electronic databases
Genealogical records

Collection procedures

Follow up procedures

In 1997, a follow-up questionnaire was sent to all cohort members who were still living in the study area; the follow-up questionnaire was extended to include information on physical activity, medical history, age at menarche, history of oral contraceptive use, age at menopause, postmenopausal hormone use, and lifestyle factors such as, cigarette smoking history, and use of dietary supplements. In 2005 saliva was started to being collected by mail, the aim is to collect saliva for all the women who still are alive. Starting in 2005 a small part of the cohorts was asked to give blood and the aim is to collect blood for 5,000 women.

Baseline principal variables of interest

Health information

Diseases history - ICD-10
Medication intake
Familial disease history
Early life
Women's health
Quality of life

Physical / Biochemical measures

Body structure measures	Biochemical measures
Body function measures

Sociodemographic Characteristics

Birth location	Parents birth location
Ethnicity/Race	Gender
Marital status	Date of birth

Socioeconomic Characteristics

Education level	Income
Working status

Life habits / Behaviours

Physical activity	Smoking / Tobacco Use
Nutrition	Alcohol intake

Physical environment

Passive smoking

Mobile phone use

Sample management

Biological samples

Blood	Buccal cells
Cord blood	Tissues
Saliva	Urine
Other (Adipose tissue)

Biological samples format

	Fresh	Frozen	Dried (paper)	Other	Specification
Blood
Saliva

Genome-Wide Association (GWA) analyses

Plan to proceed to GWA analyses later

GOVERNANCE

	Legend Yes No

Allow access to data or samples to external researchers

	Academia	Industry
Data (questionnaire-derived, measured…)
Biological samples

STATUS

Current status

Phase	Start	End
Preparation phase/Pilot	1986	1986
Recruitment / initial data collection	1987	1990
Follow-up of participants	1987	2007

Supplementary informations

The study is still ongoing but no new participants will be recruited.

Current number of participants recruited	66651 in date of 01/01/2010

Current number of collected DNA samples	13444 in date of 01/01/2010

AVAILABLE DOCUMENTS

	Document type	Availability
1	General study protocol	niclas.hakansson@ki.se
2	Specific protocols/procedures (data collection, samples management, etc.)	niclas.hakansson@ki.se
3	Questionnaires	niclas.hakansson@ki.se
4	Physical and cognitive measures
5	DNA processing
6	IT
7	Ethics
8	Consent forms	niclas.hakansson@ki.se
9	Pamphlet / project description	niclas.hakansson@ki.se
10	Governance / ethics documentation	niclas.hakansson@ki.se
11	Many details about our cohort can be obatained from the Methods part in our publications	niclas.hakansson@ki.se

PUBLICATIONS AND RELEVANT DOCUMENTATION

Publication url

http://www.imm.ki.se/smc/publications/allpubs.html

1: Wolk A prospective study of association of monounsaturated and other types of fat with risk of breast cancer. Arch Intern Med 1998 41-45
2: Wolk Long-term fatty fish consumption and renal cell carcinoma incidence in a population-based prospective cohort of women. JAMA 2006 1371-6

Detail
Question Block Annotation

General Information

Name	SMC 1997
Last update	03/12/2010
Version or reference year	1997
Phase	Second questionnaire (first questionnaire 1987)
Year interval	1987 to 1997

Questionnaire owner

Alicja Wolk

Contact

Alicja Wolk (Professor)

Karolinska Institutet
Stockholm 171 77
Phone: +46 8 5248 6170
Email: Alicja.Wolk@ki.se

Utilization conditions

No restrictions, but Professor Alicja Wolk has to be contacted and informed about use.

Information on validity

Questionnaire is validated. For unpublished information, please contact Professor Alicja Wolk.

References

Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue - http://www.ajcn.org/cgi/content/abstract/70/1/21
Reproducibility and validity of dietary glycemic index, dietary glycemic load, and total carbohydrate intake in 141 Swedish men - http://www.ncbi.nlm.nih.gov/pubmed/15226472?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=6
The validity and reproducibility of food-frequency questionnaire-based total antioxidant capacity estimates in Swedish women - http://www.ncbi.nlm.nih.gov/pubmed/18469246?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2
The validity of questionnaire-based micronutrient intake estimates is increased by including dietary supplement use in Swedish men - http://www.ncbi.nlm.nih.gov/pubmed/15226472?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=6

Methods

	Legend Yes No

Respondent

Participant
Proxy

Administration environment

Over the phone
Hospital, clinic, university or recruitment center
Respondent / Proxy residence

Administration mode

Auto administered
Auto administrated with face to face validation by trained personnel
Administrated by trained personel / Physician
Other (By mail)

Administration format

Paper questionnaire
Computerized

Administration language

English
Swedish

Documents

Available Format

NOTICE: HTML document format may differ slightly from the actual questionnaire. Please refer to the original PDF document for exact reproduction.

Comment

The SMC 1997 Questionnaire was used as an example in the reference below :
Wolk A, Larsson SC, Johansson JE, Ekman P.
Long-term fatty fish consumption and renal cell carcinoma incidence in women.
JAMA. 2006 Sep 20;296(11):1371-6.

Questionnaires used in the SMC (the english version is not yet available on the web):
1987-1990 http://ki.se/content/1/c6/05/39/87/SMC1987.pdf
1997 http://ki.se/content/1/c6/05/39/87/SMC1997.pdf
2008 http://ki.se/content/1/c6/05/39/87/SMC2008.pdf
2009 http://ki.se/content/1/c6/05/39/87/SMC2009.pdf

The SMC 1997 questionnaire is very similar to the COSM 1997 questionnaire

General Information

Name	SMC 1997
Number of Question Blocks	30

Questionnaire and Question Block List

Click on the

to see the block of questions related to a domain or a group of domains.

Block 1

Health Information / Participants Early Life Conditions / Participant's Birth weight

Block 2

Health Information / Participants Early Life Conditions

Block 3

Sociodemographic Characteristics / Kinship

Block 4

Body structures / Anthropometric structures / Anthropometric measures / Height

Block 5

Body structures / Anthropometric structures / Anthropometric measures / Weight

Block 6

Life Habits/Behaviours / Weight related behaviours

Block 7

Life Habits/Behaviours / Physical activity / Activities/Exercise and Frequency

Block 8

Life Habits/Behaviours / Sleep Behaviours

Block 9

Life Habits/Behaviours / Alcohol use
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Beverages (other than water or alcohol)
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Caffeine
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Cereals, Bread, Starches
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Fat Intake
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Milk products
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Salt and Food Supplement

Block 10

Life Habits/Behaviours / Nutrition / Food intake and Frequency / Cereals, Bread, Starches
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Fat Intake

Block 11

Life Habits/Behaviours / Nutrition / Food intake and Frequency / Fat Intake

Block 12

Life Habits/Behaviours / Nutrition / Food intake and Frequency / Beverages (other than water or alcohol)
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Cereals, Bread, Starches
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Meat, Eggs, Fish and Alternatives
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Sweets, Baked goods
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Vegetables and Fruits

Block 13

Life Habits/Behaviours / Nutrition / Food intake and Frequency / Meat, Eggs, Fish and Alternatives

Block 15

Life Habits/Behaviours / Alcohol use

Block 16

Health Information / Medication Intake (ATC/DDD) / Cardiovascular system (C)
Health Information / Medication Intake (ATC/DDD) / Various
Life Habits/Behaviours / Nutrition / Food intake and Frequency / Salt and Food Supplement

Block 17

Health Information / Women's health / Menstruation

Block 18

Health Information / Reproductive history / Number of children

Block 19

Health Information / Individual Disease history / Diseases of the genitourinary system
Health Information / Medical Health Intervention (C239) / Physical/Physiological Therapeutic Interventions / Therapeutic Interventions on the Genitourinary System

Block 20

Health Information / Medication Intake (ATC/DDD) / Genito urinary system and sex hormones (G)

Block 21

Health Information / Women's health / Menstruation

Block 22

Health Information / Medication Intake (ATC/DDD) / Genito urinary system and sex hormones (G)

Block 23

Health Information / Individual Disease history / Diseases of the circulatory system
Health Information / Individual Disease history / Diseases of the digestive system
Health Information / Individual Disease history / Diseases of the eye and adnexa
Health Information / Individual Disease history / Diseases of the genitourinary system
Health Information / Individual Disease history / Diseases of the musculoskeletal system and connective tissue
Health Information / Individual Disease history / Diseases of the respiratory system
Health Information / Individual Disease history / Endocrine, nutritional and metabolic diseases
Health Information / Individual Disease history / Injury, poisoning and certain other consequences of external causes
Health Information / Individual Disease history / Neoplasms

Block 24

Health Information / Medication Intake (ATC/DDD) / Alimentary tract and metabolism (A)
Health Information / Medication Intake (ATC/DDD) / Cardiovascular system (C)
Health Information / Medication Intake (ATC/DDD) / Dermatologicals (D)
Health Information / Medication Intake (ATC/DDD) / Musculo-skeletal system (M)
Health Information / Medication Intake (ATC/DDD) / Nervous system (N)
Health Information / Medication Intake (ATC/DDD) / Respiratory system (R)
Health Information / Medication Intake (ATC/DDD) / Sensory organs (S)
Health Information / Medication Intake (ATC/DDD) / Systemic hormonal preparations, excl. Sex hormones and insulins (H)

Block 25

Health Information / Familial Disease History (ICD10*) / Diseases of the circulatory system
Health Information / Familial Disease History (ICD10*) / Neoplasms

Block 26