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Cambridge City over - 75s Cohort Study (The) [CC75C] Download as PDF

GENERAL INFORMATION

Name Cambridge City over - 75s Cohort Study (The)
Acronym CC75C
Last update 09/11/2013

Affiliation

    Principal investigators

    Jane Flemming (Senior Research Associate/Dr.)
    University of Cambridge, The primary care unit
    Tom R Dening (Medical Director/Dr)
    Cambridgeshire & Peterborough Mental Health Partnership NHS Trust
    Carol Brayne (Professor of Public Health Medicine/Prof.)
    University of Cambridge, Department of Public Health and Primary Care
    Stephen Barclay (HEFCE Clinical Senior Lecturer/ Honorary Consultant Physician/Dr.)
    University of Cambridge, The primary care unit
    Morag Farquhar (Senior Research Associate/Dr.)
    University of Cambridge, The primary care unit
    Ann Louise Kinmonth (CBE – Emeritus Professor of General Practice/Prof)
    University of Cambridge, The primary care unit
    Eugene S Paykel (Professor of Psychiatry (retired)/Prof)
    University of Cambridge, Department of Psychiatry

    Contacts

    Jane Fleming (Research Nurse and Study Co-ordinator/Dr)
    University of Cambridge, Department of Public Health and Primary Care
    Cambridge CB2 0SR
    Phone: +44 (0) 1223 330341
    Email:
    Emily Zhao (Computer Officer/Ms.)
    University of Cambridge, Department of Public Health and Primary Care
    Cambridge CB2 0SR
    Phone: +44 (0) 1223 330341
    Email:

    Website

    • http://www.cc75c.group.cam.ac.uk/External

    Funding agency

    Percentage Category
    National Institute for Health Research, UK -- Public Funding
    Dementia and Neurodegenerative Diseases Research Network -- Public funding
    The BUPA Foundation -- Charity

    OBJECTIVES

    The study’s core themes – cognition and function in older old age – cover multidisciplinary research interests as diverse as neuropsychology, genetics, palliative care and psychiatry with a range of investigations at various time-points including bone strength, falls, physical performance and brain pathology. Each survey has included a detailed cognitive assessment. The combination of biological (neuropathological and genetic) data and life factors measured longitudinally in a population-based sample allow examination of how these factors interact to bring about the clinical manifestations of cognitive impairment and dementia.

    Research Focus

    • No Broad approach with no specific target of interest (study built as an infrastructure for a broad range of unspecified scientific activities/questions).
    • Yes Target specific questions of interest (predefined scientific targets like, cardiovascular diseases, social environment, specific health trajectories etc.)
    Topics ICD-10 classificationExternal
    Yes Mental and behavioural disorders (F00-F99)
    Yes Diseases of the nervous system (G00-G99)

    METHODS

    Legend Yes No Unknown

    General design

    Study design Cohort
    Type of participants Individuals
    Target or final number of participants 2166
    Target or final number of DNA 406

    Participant selection / Characteristics of the population

    Selection criteria

    Yes Age Minimun: 75 years   
    Yes Country of residence United Kingdom (Cambridge)

    Data Sources

      Cross-sectional Longitudinal follow-up
    Yes Questionnaires to participants/respondents No Yes
    Yes Direct physical measures Yes No
    Yes Biological samples Yes No

    Sample management

    Biological samples

    Yes Blood Unknown Buccal cells
    No Cord blood Yes Tissues (Brain tissues)
    Unknown Saliva Unknown Urine

    Genome-Wide Association (GWA) analyses

    • Yes Plan to proceed to GWA analyses later

    GOVERNANCE

    Legend Yes No

    Allow access to data or samples to external researchers

    Academia Industry
    Yes Data (questionnaire-derived, measured…) Yes
    Yes Biological samples Yes

    STATUS

    Current status

    Phase Start End
    Preparation phase/Pilot -- --
    Baseline recruitment / initial data collection 1985 1987
    Follow-up of participants 1985 2011

    Supplementary informations

    Survey -Baseline recruitment/ initial data collection (1985-1987), Survey 2 (1988-1993), Survey 3 (1992-1995), Survey 4 (1995-1995), Survey 5 (1998-1999), Survey 6 (2002-2003), Survey 7 (2006-2007), Survey 8 (2008-2009), Survey 9 (2010-2011)

    Current number of participants recruited 2166
    Current number of collected DNA samples 406

    blood and/or brain tissue

    PUBLICATIONS AND RELEVANT DOCUMENTATION

    Publication url

    http://www.cc75c.group.cam.ac.uk/pages/journals/default.htmExternal

    COMMENT

    Following variables of interest are not collected at baseline but in subsequent surveys:
    - Diseases history;
    - Medication intake;
    - Quality of life;
    - Anthropometric measures;
    - Physical activity;
    - Smoking/Tobacco use;
    - Alcohol intake.


    This Catalogue was archived on: 2013-12-09. Information included in this Catalogue is for informational purposes only.

    GENERAL INFORMATION

    Study name Cambridge City over - 75s Cohort Study (The) [CC75C]
    Last update 08/28/2008
    Collected at phase MMSE, Self reported physical condition and ADL were measured in all surveys

    Contacts

    Jane Fleming (Research Nurse and Study Co-ordinator/Dr)
    Cambridge CB2 0SR
    Phone: +44 (0) 1223 330341
    Email:

    Physical and cognitive measures collected

    Legend Yes No

    BODY STRUCTURES

    ANTHROPOMETRIC STRUCTURES

    Anthropometric measures

    Yes Weight (Survey 3-Survey 7: Have you lost or gained al lot of weight in the last six month)

    Yes Height (Survey 6)

    Yes Standing height

    Body composition

    Yes Others body composition measures (Survey 6: Quantitative ultrasound heel scans.)

    BODY FUNCTIONS

    MENTAL FUNCTIONS

    Global mental functions

    Yes Cognitive functions (MMSE scores, full CAMCOG and CAMDEX interviews.)

    Specific mental functions

    Yes Attention functions

    Yes Memory functions

    Yes Psychomotor functions

    SENSORY FUNCTIONS AND PAIN

    Seeing and related functions

    Yes Vision and related functions (Survey1 - 7: self report poor vision. Survey 4-6 survey 6: Vision test.)

    Hearing and vestibular functions

    Yes Hearing (Survey 1 -7: Self report poor hearing. Survey 4-6: Hearing test.)

    VOICE AND SPEECH FUNCTIONS

    Fluency and rhythm of speech functions

    Yes Speech fluency (Survey 1 - 7: Interviewer assessment on unclear speech.)

    NEUROMUSCULOSKELETAL AND MOVEMENT-RELATED FUNCTIONS

    Yes Grip strength (Survey 6)

    Yes Sit and reach (Reaching up to comb hair or down to cut toenails)

    Yes Other measures of the neuromusculoskeletal system and movement-related function (survey 6: Short Physical Performance Battery, including balance tests, gait speed, and chair stands)

    OTHER BODY FUNCTIONS

    Other measures of the body functions

    ADL questions

    ACTIVITIES AND PARTICIPATIONS

    LEARNING AND APPLYING KNOWLEDGE

    Yes Learning (In survey 1 only: how old when lft wchool. How many years on further training.)

    Administration mode

    Legend Yes No

    Administration environment

    No Hospital, clinic, university or recruitment center

    Yes Participant residence

    No Other

    Staff administering test

    Yes Professionals (nurses, clinicians, etc)

    Yes Interviewers/research assistants

    No Other

    Documentation on procedures

    Administration language English
    © 2005 Public Population Project in Genomics.
    All rights reserved.
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