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10 001 Dalmatians study of Croatian island isolates [10 001 Dalmatians] Download as PDF


Name 10 001 Dalmatians study of Croatian island isolates
Acronym 10 001 Dalmatians
Last update 09/11/2013


    Principal investigator

    Ozren Polasek (Project coordinator/MD, PhD)
    Department of Public Health, Split University School of Medicine


    Ozren Polasek (Project coordinator/MD, PhD)
    Department of Public Health, Split University School of Medicine
    Split 21000
    Phone: +38521557920


    No information available

    Funding agency

    Percentage Category
    EU FP6 EUROSPAN 10% public funding organization
    Ministry of Science, Education and Sports of the Republic of Croatia 10% ministry
    Medical Research Council UK 70% public funding organization


    To study the genetic and environmental determinants of health and disease in genetic-isolate island populations from Dalmatia, Croatia.

    Research Focus

    • Yes Broad approach with no specific target of interest (study built as an infrastructure for a broad range of unspecified scientific activities/questions).
    • No Target specific questions of interest (predefined scientific targets like, cardiovascular diseases, social environment, specific health trajectories etc.)


    Legend Yes No Unknown

    General design

    Study design Cross-sectional prevalence, Cohort, Initially cross-sectional, with a tendency of transforming towards cohort study.
    Type of participants Individuals, Families
    Target or final number of participants 10001
        Target or final number of families 7000
    Target or final number of DNA 10001

    Participant selection / Characteristics of the population

    Selection criteria

    Yes Country of residence Croatia (Dalmatia)

    Supplementary informations

    The 9 settlements were carefully chosen in 2002 based on their current population sizes, historic records, demographic information and accessibility of genealogical records to present a wide range of different ethnic histories, fluctuations in population size, admixture, and bottleneck events for the first lot of 1,000 subjetcs; other subjects were recruited in a similar way in other regions/locations; the last cohort was selected from the coastal city of Split.

    Data Sources

      Cross-sectional Longitudinal follow-up
    Yes Questionnaires to participants/respondents Yes No
    Yes Direct physical measures Yes Yes
    Yes Biological samples Yes No
    Yes Genealogical records

    Sample management

    Biological samples

    Yes Blood No Buccal cells
    No Cord blood No Tissues
    No Saliva Yes Urine

    Genome-Wide Association (GWA) analyses

    • Yes Already or currently generating GWA data. Approximate number of participants : 2500
    • Yes Plan to proceed to GWA analyses later


    Legend Yes No

    Allow access to data or samples to external researchers

    Academia Industry
    Yes Data (questionnaire-derived, measured…) Yes
    No Biological samples


    Current status

    Phase Start End
    Preparation phase/Pilot 2001 --
    Baseline recruitment / initial data collection 2002 --
    Follow-up of participants 2007 --
    Current number of participants recruited 5100 in date of 01/01/2011
    Current number of collected DNA samples 5100 in date of 01/01/2011


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