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Avon Longitudinal Study of Parents and Children [ALSPAC] Download as PDF

GENERAL INFORMATION

Name Avon Longitudinal Study of Parents and Children
Acronym ALSPAC
Last update 09/11/2013

Affiliation

    Principal investigators

    Caroline Relton (Dr.)
    Alan Edmond (Dr.)
    University of Bristol
    Debbie Lawlor
    David Evans
    John Macleod
    Susan Ring
    Kate Tilling (Dr.)
    University of Bristol
    Nicholas Timpson
    Lynn Molloy
    John Lynch
    Richard Paul Burton (Prof.)
    University of Leicester
    Glynn Lewis (Dr.)
    University of Bristol
    Andrew Ness (Dr.)
    University of Bristol
    Jenny Donovan
    George Davey-Smith (Prof./ Principal investigator)
    University of Bristol
    Beate Glaser
    John Henderson (Dr.)
    University of Bristol
    Jonathon Tobias

    Contact

    Lynn Molloy
    University of Bristol
    Bristol BS8 1TH
    Phone: 0117 331 0075
    Email:

    Website

    • http://www.bristol.ac.uk/alspac/External

    Funding agency

    Percentage Category
    National Institute of Health -- --
    DfES -- --
    University of Bristol -- --
    Medical Research Council -- --
    ESRC -- --
    Centres for Disease Control -- --
    European Commission -- --
    Wellcome Trust -- --

    OBJECTIVES

    The aim of ALSPAC is to determine which biological, environmental, social, psychological and psychosocial factors are associated with the survival and optimal health and development of the fetus, infant and child, and the ways in which causal relationships might vary with the genetic composition of mother and/or child.

    To identify the complex ways in which environmental features may be associated with the optimal development, health and well-being of the child, will involve a study of the ways in which genes and the environment interact. A child's ability to meet environmental and social challenges is influenced by genetic variation, but the interactions are complex. Genetic susceptibility or resistance to common disorders is likely to be bestowed by one or more genetic polymorphisms, the impact of which will change as various environmental and developmental stresses on the child change. ALSPAC was specifically designed to analyse this interplay between genes and environment with respect to important relatively common health outcomes.

    METHODS

    Legend Yes No Unknown

    General design

    Study design Cohort
    Type of participants Families
    Target or final number of participants 22785
      10 570 mothers
        Target or final number of families No information available
    Target or final number of DNA No information available

    Participant selection / Characteristics of the population

    Selection criteria

    Yes Gravidity (pregnant women)
    Yes Country of residence United Kingdom (Avon)
    Yes Other criteria Mothers had to be resident in Avon while pregnant. Date of delivery had to lie between 1st April 1991 and 31st December 1992 inclusive.

    Data Sources

      Cross-sectional Longitudinal follow-up
    Yes Questionnaires to participants/respondents No Yes
    Yes Direct physical measures No Yes
    Yes Biological samples No Yes

    Sample management

    Biological samples

    Yes Blood Yes Buccal cells
    Yes Cord blood Yes Tissues
    Unknown Saliva Unknown Urine
    Yes Other (hair, nails)

    GOVERNANCE

    Legend Yes No

    Allow access to data or samples to external researchers

    Yes Data (questionnaire-derived, measured…)
    Yes Biological samples

    STATUS

    Current status

    Phase Start End
    Preparation phase/Pilot 1985 1991
    Baseline recruitment / initial data collection 1991 1992
    Follow-up of participants 1991 --

    Supplementary informations

    now includes the study of the Fathers of the Children of the 90s, as well as the Children of the Children of the 90s and most recently the siblings of the Children of the 90s.

    Current number of participants recruited 22785 in date of 10/01/2007
    Current number of collected DNA samples 23271 in date of 11/28/2012

    10,643 young people, 11,697 mothers and 931 partners

    PUBLICATIONS AND RELEVANT DOCUMENTATION

    Marker paper describing the study

    http://www.bristol.ac.uk/alspac/researchers/research/papers/External

    Publication url

    http://www.bristol.ac.uk/alspac/sci-com/pubs/External

    COMMENT

    20,800 DNA samples at present [Nov 2007] consist of approx 10,000 mothers, 10,000 children and 800 fathers. The latter are from buccal cells. Ultimately, the aim is to get DNA from as many of the participants as possible. Lymphocytes are gradually being transformed to generate cell lines (again on as many as possible).


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