|Name||Alpha-Tocopherol, Beta-Carotene Cancer Prevention|
No information available
|Phone: 358 9 4744 8740 (Finland)
|Phone: +358 (0) 20 610 6000
|National Cancer Institute
Markus Perola (Dr.)
|National Biobank of Finland
To investigate whether daily supplementation with alpha-tocopherol, beta-carotene, or both would reduce the incidence of lung or other cancers among male smokers.
|Legend Yes No Unknown|
|Study design||Clinical trial / intervention trial|
|Type of participants||Individuals, Random assignement of the participants to one of four groups that received for 5-8 years: 1) alpha-tocopherol (50 mg/day), 2) beta-carotene (20 mg/day), 3) both supplements or 4) placebo capsules.|
|Supplementary informations||Random assignement of the participants to one of four groups that received for 5-8 years:
1) alpha-tocopherol (50 mg/day),
2) beta-carotene (20 mg/day),
3) both supplements or
4) placebo capsules.
|Target or final number of participants||29133|
|Target or final number of DNA||No information available|
|Age||Minimun: 50 years Maximun: 69 years|
|Country of residence||Finland|
|Other criteria||Men who smoked at least five cigarettes per day and reside in the southwestern Finland.|
|Baseline recruitment / initial data collection||1985||1988|
|Follow-up of participants||1985||1993|
1) three annual visits,
2) at 3 years, food frequency questionnaire,
3) follow-up through Cancer Registry and governmental databases.
Several blood samples from each participant.
Participants have been followed since 1993 to evaluate the long-term effects of the vitamins on cancer incidence, and on overall and cause-specific mortality.
|Current number of participants recruited||29133|
|Current number of collected DNA samples||29133|