Alpha-Tocopherol, Beta-Carotene Cancer Prevention [ATBC] 
GENERAL INFORMATION
| Name | Alpha-Tocopherol, Beta-Carotene Cancer Prevention |
|---|---|
| Acronym | ATBC |
| Last update | 09/11/2013 |
Affiliation
Principal investigator
No information available
Contacts
|
Heleena Juola
|
Phone: 358 9 4744 8740 (Finland) Email: |
|
Helena Kaariainen
|
Phone: +358 (0) 20 610 6000 Email: |
|
Demetrius Albanes
|
National Cancer Institute Phone: 011-358-0-947-441 Email: |
|
Markus Perola (Dr.)
|
National Biobank of Finland Helsinki 00251 Phone: +358-40-8612557 Email: |
Website
- http://dceg.cancer.gov/atbcstudy/study_details.html
OBJECTIVES
To investigate whether daily supplementation with alpha-tocopherol, beta-carotene, or both would reduce the incidence of lung or other cancers among male smokers.
METHODS
Legend  Yes  No  Unknown |
General design
| Study design | Clinical trial / intervention trial |
|---|---|
| Type of participants | Individuals, Random assignement of the participants to one of four groups that received for 5-8 years: 1) alpha-tocopherol (50 mg/day), 2) beta-carotene (20 mg/day), 3) both supplements or 4) placebo capsules. |
| Supplementary informations | Random assignement of the participants to one of four groups that received for 5-8 years: 1) alpha-tocopherol (50 mg/day), 2) beta-carotene (20 mg/day), 3) both supplements or 4) placebo capsules. |
| Target or final number of participants | 29133 |
| Target or final number of DNA | No information available |
Participant selection / Characteristics of the population
Selection criteria
| Gender |
Men |
| Age |
Minimun: 50 years Maximun: 69 years |
| Country of residence |
Finland |
| Other criteria |
Men who smoked at least five cigarettes per day and reside in the southwestern Finland. |
STATUS
Current status
| Phase | Start | End |
|---|---|---|
| Preparation phase/Pilot | 1984 | 1985 |
| Baseline recruitment / initial data collection | 1985 | 1988 |
| Follow-up of participants | 1985 | 1993 |
Supplementary informations
Follow-up:
1) three annual visits,
2) at 3 years, food frequency questionnaire,
3) follow-up through Cancer Registry and governmental databases.
Several blood samples from each participant.
Participants have been followed since 1993 to evaluate the long-term effects of the vitamins on cancer incidence, and on overall and cause-specific mortality.
| Current number of participants recruited | 29133 |
|---|
| Current number of collected DNA samples | 29133 |
|---|
