Cambridge City over - 75s Cohort Study (The) [CC75C]

GENERAL INFORMATION

Name	Cambridge City over - 75s Cohort Study (The)
Acronym	CC75C
Last update	07/22/2009

Affiliation

• Biobanking and Biomolecular Resources Research Infrastructure [BBMRI]

Principal investigators

Carol Brayne (Professor of Public Health Medicine/Prof.)	University of Cambridge, Department of Public Health and Primary Care
Felicia A Huppert (Reader in Psychology/Dr)	University of Cambridge, Department of Psychiatry
Tom R Dening (Medical Director/Dr)	Cambridgeshire & Peterborough Mental Health Partnership NHS Trust
Eugene S Paykel (Professor of Psychiatry (retired)/Prof)	University of Cambridge, Department of Psychiatry

Contacts

Jane Fleming (Research Nurse and Study Co-ordinator/Dr)	University of Cambridge, Department of Public Health and Primary Care Cambridge CB2 0SR Phone: +44 (0) 1223 330341 Email: jane.fleming@phpc.cam.ac.uk
Emily Zhao (Computer Officer/Ms.)	University of Cambridge, Department of Public Health and Primary Care Cambridge CB2 0SR Phone: +44 (0) 1223 330341 Email: ez219@medschl.cam.ac.uk

Website

• http://www.cc75c.group.cam.ac.uk/

Funding agency

	Percentage	Category
Dementia and Neurodegenerative Diseases Research Network	--	Public funding
The BUPA Foundation	--	Charity
National Institute for Health Research, UK	--	Public Funding

BACKGROUND

The Cambridge City over-75s Cohort Study (CC75C) is a long-term follow-up study of a representative population sample of 2,166 people aged 75 and older, begun in 1985.
The study’s origins lie in a survey of dementia prevalence, the Hughes Hall Project for Later Life, which began in 1985 and its first follow-up dementia incidence study, the Cambridge Project for Later Life. The first study targeted all men and women aged 75 or older who were registered with geographically and socially representative general practices in Cambridge, and achieved a 95% response rate. From this original survey of 2,610 people, 2,166 individuals form the baseline sample for the longitudinal cohort which excluded one of the original general practices because of differential recruitment and a sub-group involved in a branch study. It is the survivors from this group – now known as the Cambridge City over-75s Cohort – who have been followed up on at least six further occasions, with sub-groups assessed more often, and those nonagenarians and centenarians still alive now continuing to be followed up. Through a series of interviews and assessments spanning over 20 years the participants have contributed to one of the largest and longest-running longitudinal observational studies of ageing into older old age. The biological collection includes blood samples collected at Year 10 and an on-going brain donation programme.

OBJECTIVES

The study’s core themes – cognition and function in older old age – cover multidisciplinary research interests as diverse as neuropsychology, genetics, palliative care and psychiatry with a range of investigations at various time-points including bone strength, falls, physical performance and brain pathology. Each survey has included a detailed cognitive assessment. The combination of biological (neuropathological and genetic) data and life factors measured longitudinally in a population-based sample allow examination of how these factors interact to bring about the clinical manifestations of cognitive impairment and dementia.

Topics of interest

• Broad approach with no specific topic of interest
• Target specific topics of interest (health outcomes, health determinants, etc.)

Topics	ICD-10 classification
Mental and behavioural disorders (F00-F99)
Diseases of the nervous system (G00-G99)

METHODS

	Legend Yes No Unknown

General design

Study design	Cohort
Type of participants	Individuals
Target or final number of participants	2166
Target or final number of DNA	406

Participant selection / Characteristics of the population

Selection criteria

Age	Minimun: 75 years
Country of residence	United Kingdom (Cambridge)

Recruitment procedures

Participants were initially identified through primary care registers - all men and women aged 75 or older registered with geographically and socially representative general practices. Letters outlining the study allowed the opportunity to refuse before one of the research team visited in person to explain in more detail and obtain consent. Interviews were conducted in the participant’s usual place of residence.

Data Sources

	Cross-sectional	Repeated/continuous
Questionnaires to participants/respondents
Direct physical measures
Biological samples
Medical paper
Electronic databases
Genealogical records

Collection procedures

Each survey has included the Cambridge Cognitive Examination (CAMCOG), a detailed cognitive assessment that includes the Mini-Mental State Examination (MMSE). Sub-samples have had detailed psychiatric assessment using the Cambridge Diagnostic Examination for the Elderly (CAMDEX) interview, detailed neuropsychological assessment and additional tests. Longitudinal data are also available on socio-demographic variables (e.g. change of residence, household structure, change in marital status, social contact), activities of daily living, use of health and social services, health problems and medication. Biological resources collected include blood and saliva samples, whilst the brain donation programme has made it possible to undertake neuro-pathological and molecular biological analyses on tissue from a representative sample of elderly people. Functional performance testing and heel ultrasound measurements of bone fragility were introduced in the sixth interview wave, which also included a year's prospective falls data collection. The focus of the seventh survey is on quality of life issues at the end of life for which we are currently interviewing relatives or carers of about fifty surviving members of the cohort all now aged 95 or more, as well as these study participants themselves.

Follow up procedures

Follow-up surveys have been every few years.

Baseline principal variables of interest

Health information

• Diseases history - ICD-10
• Medication intake
• Familial disease history
• Early life
• Women's health
• Quality of life

Physical / Biochemical measures

Body structure measures	Biochemical measures
Body function measures

Sociodemographic Characteristics

	Gender
Marital status	Date of birth

Socioeconomic Characteristics

Education level	Income
Working status

Life habits / Behaviours

Physical activity	Smoking / Tobacco Use
Nutrition	Alcohol intake

Physical environment

Passive smoking

Mobile phone use

Sample management

Biological samples

Blood	Buccal cells
Cord blood	Tissues (Brain tissues)
Saliva	Urine

Biological samples format

	Fresh	Frozen	Dried (paper)	Other	Specification
Blood
Tissues					(Brain tissues)

Genome-Wide Association (GWA) analyses

• Plan to proceed to GWA analyses later

GOVERNANCE

	Legend Yes No

Allow access to data or samples to external researchers

	Academia	Industry
Data (questionnaire-derived, measured…)
Biological samples

STATUS

Current status

Phase	Start	End
Preparation phase/Pilot	--	--
Recruitment / initial data collection	1985	1987
Follow-up of participants	1985	--

Current number of participants recruited	2166

Current number of collected DNA samples	406

blood and/or brain tissue

Participation rate	95% in date of 01/01/1987

AVAILABLE DOCUMENTS

	Document type	Availability
1	General study protocol	http://www.cc75c.group.cam.ac.uk/
2	Specific protocols/procedures (data collection, samples management, etc.)	jane.fleming@phpc.cam.ac.uk
3	Questionnaires	http://www.cc75c.group.cam.ac.uk/
4	Consent forms	http://www.cc75c.group.cam.ac.uk/
5	Governance / ethics documentation	jane.fleming@phpc.cam.ac.uk

PUBLICATIONS AND RELEVANT DOCUMENTATION

Publication url

http://www.cc75c.group.cam.ac.uk/pages/journals/default.htm

COMMENT

Following variables of interest are not collected at baseline but in subsequent surveys:
- Diseases history;
- Medication intake;
- Quality of life;
- Anthropometric measures;
- Physical activity;
- Smoking/Tobacco use;
- Alcohol intake.

General information

Name	Physical and cognitive measures
Last update	07/27/2010
Collected at phase	MMSE, Self reported physical condition and ADL were measured in all surveys

Contacts

Jane Fleming (Research Nurse and Study Co-ordinator/Dr)

Cambridge CB2 0SR Phone: +44 (0) 1223 330341 Email: jane.fleming@phpc.cam.ac.uk

Physical and cognitive measures collected

	Legend Yes No

BODY STRUCTURES

ANTHROPOMETRIC STRUCTURES

Anthropometric measures

Weight (Survey 3-Survey 7: Have you lost or gained al lot of weight in the last six month)

Height (Survey 6)

Standing height

Body composition

Others body composition measures (Survey 6: Quantitative ultrasound heel scans.)

BODY FUNCTIONS

MENTAL FUNCTIONS

Global mental functions

Cognitive functions (MMSE scores, full CAMCOG and CAMDEX interviews.)

Specific mental functions

Attention functions

Memory functions

Psychomotor functions

SENSORY FUNCTIONS AND PAIN

Seeing and related functions

Vision and related functions (Survey1 - 7: self report poor vision. Survey 4-6 survey 6: Vision test.)

Hearing and vestibular functions

Hearing (Survey 1 -7: Self report poor hearing. Survey 4-6: Hearing test.)

VOICE AND SPEECH FUNCTIONS

Fluency and rhythm of speech functions

Speech fluency (Survey 1 - 7: Interviewer assessment on unclear speech.)

NEUROMUSCULOSKELETAL AND MOVEMENT-RELATED FUNCTIONS

Grip strength (Survey 6)

Sit and reach (Reaching up to comb hair or down to cut toenails)

Other measures of the neuromusculoskeletal system and movement-related function (survey 6: Short Physical Performance Battery, including balance tests, gait speed, and chair stands)

OTHER BODY FUNCTIONS

Other measures of the body functions

ADL questions

ACTIVITIES AND PARTICIPATIONS

LEARNING AND APPLYING KNOWLEDGE

Learning (In survey 1 only: how old when lft wchool. How many years on further training.)

Administration mode

	Legend Yes No

Administration environment

Hospital, clinic, university or recruitment center

Participant residence

Other

Staff administering test

Professionals (nurses, clinicians, etc)

Interviewers/research assistants

Other

Documentation on procedures

Administration language	English

General Information

Name	Information Technologies
Study name	Cambridge City over - 75s Cohort Study (The) [CC75C]
Last update	02/22/2010

Contact

Emily Zhao (Computer Officer/Ms.)

Institute of Public Health, University of Cambridge Cambridge CB2 0SR Phone: +44 (0) 1223 330341 Email: ez219@medschl.cam.ac.uk

Software

	Legend Yes No

Comments

No information available