| Name | 45 and Up Study (The) |
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| Last update | 01/18/2010 |
Principal investigators
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Louisa Jorm (Professor / Research Director)
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The Sax Institute |
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Emily Banks (Professor)
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The Sax Institute |
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Sonia Wutzke (Dr. / Research Assets Director)
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The Sax Institute |
Contact
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The 45 and Up Study
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Phone:
1300 45 11 45
Email: 45andup@saxinstitute.org.au |
Website
Funding agencies
Unprecedented changes to the structure of the Australian population are predicted for the near future such that the over 65 age group is likely to increase by around 50% in the next 15-20 years. The rapidity and scale of this population ageing highlights the need for timely and reliable evidence regarding the key factors impacting on the health of older people in Australia. Comprehensive investigation of the determinants of healthy ageing incorporates assessment of disease risk, quality of life and other indices, in relation to a very wide range of possible exposures, including social and psychological factors, with consideration of how these exposures might interact with one another. A large scale cohort study of individuals aged 45 and over will provide information on a wide range of exposures and outcomes of public health importance for the ageing population. At the same time as providing timely and reliable answers to specific research questions, the cohort study will serve as a framework for a range of future research activities and will answer important predictable and unforeseen questions unable to be addressed by other study designs, including the effect of a risk factor on a range of conditions.
The aim is to set up a large-scale population-based cohort study of 250,000 individuals aged 45 and over in New South Wales (equal to around 10% of the general population of New South Wales in this age group), to address the following priority research areas and questions and to provide a long term resource for public health research:
1. Examination of the socioeconomic determinants of healthy ageing, including rural/urban inequalities, effect of retirement, social capital and variations in healthy ageing by ethnicity and social class.
2. Investigation of the health effects of obesity, overweight and physical activity, with a particular focus on the risk of cancer, cardiovascular disease, diabetes mellitus and all cause mortality.
3. Investigation of risk factors for and the detection and management of cancer, including investigation of prostate cancer and prostate cancer screening.
4. Investigation of risk factors for and management of cardiovascular disease.
5. Investigation of impact of environmental factors on healthy ageing.
6. Examination of risk factors for mental health problems in later life, including depression, and use of mental health services.
7. Investigation of use of health services in relation to ageing, including the determinants of use of residential aged care.
8. Investigation of health in people 80 and over (the “old old”).
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Legend
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| Study design | Cohort |
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| Type of participants | Individuals |
| Target or final number of participants | 260000 |
| Target or final number of DNA | No information available |
Selection criteria
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Minimun: 45 years Maximun: 106 years |
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Australia (New South Wales) |
Recruitment procedures
Individuals aged 45 and over and resident in New South Wales were randomly sampled from the Medicare Australia enrolment database.The study over-sampled, by a factor of two, individuals aged 80 years and over and people resident in rural and remote areas. People also could volunteer to join the study.
Data Sources
| Cross-sectional | Repeated/continuous | |
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Follow up procedures
Repeat questionnaires to all cohort members to update exposure data and health status are planned at 5-yearly intervals. Participants will also be invited from time to time to participate in targeted sub-studies where additional information will be requested.
Baseline principal variables of interest
Health information
Physical / Biochemical measures
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Sociodemographic Characteristics
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Socioeconomic Characteristics
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Life habits / Behaviours
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Physical environment
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Sample management
Biological samples
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Legend
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Allow access to data or samples to external researchers
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Current status
| Phase | Start | End |
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| Preparation phase/Pilot | 2005 | 2005 |
| Recruitment / initial data collection | 2006 | 2008 |
| Follow-up of participants | -- | -- |
| Current number of participants recruited | 260000 in date of 04/01/2010 |
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| Current number of collected DNA samples | 400 in date of 09/09/2009 |
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With sufficient funding, all members of the cohort will be invited to provide biological samples. The first 2,000 participants have already invited.
| Participation rate | 18% |
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| Document type | Availability | |
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| 1 | General study protocol | |
| 2 | Specific protocols/procedures (data collection, samples management, etc.) |
45andup@saxinstitite.org.au |
| 3 | Questionnaires | |
| 4 | Consent forms |
45andup@saxinstitite.org.au |
| 5 | Pamphlet / project description | |
| 6 | Governance / ethics documentation |
45andup@saxinstitite.org.au |
Publication url
http://www.45andup.org.au/studymaterials.aspx?page=scientificpapersandjournalarticles
| Name | 45 and Up Study Baseline Questionnaire for Men |
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| Last update | 04/02/2010 |
| Version or reference year | Questionnaire for Men: V0 2005, V1 2006, V2 2007, V3 2008-2009 |
| Phase | Baseline |
| Year interval | 2005 to 2009 |
Questionnaire owner
Contact
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Emily Banks (Professor)
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Sax Institute
Sydney Phone: 1300 45 11 45 Email: 45andup@saxinstitute.org.au |
Utilization conditions
The questionnaire is the intellectual property of the Sax Institute. Any party wishing to use the questionnaire must first seek permission from the Sax Institute.
Information on validity
The original questionnaire was refined in subsequent versions. Most participants (>85%) completed the final refined version. The refinements are not substantive changes and generally validity is unaffected. There are a small number of variables where changes to the question have affected the data. These are fully documented with processing algorithms developed to harmonise differences from changes to the questionnaire. Both documentation and data processing syntax are available to researchers.
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Legend
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Respondent
Administration environment
Administration mode
Administration format
Administration language
Available Format
NOTICE: HTML document format may differ slightly from the actual questionnaire. Please refer to the original PDF document for exact reproduction.
| Name | 45 and Up Study Baseline Questionnaire for Men |
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| Number of Question Blocks | 46 |
| Name | 45 and Up Study Baseline Questionnaire for Women |
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| Last update | 04/02/2010 |
| Version or reference year | Questionnaire for Women: V0 2005, V1 2006, V2 2007, V3 2008-2009 |
| Phase | Baseline |
| Year interval | 2005 to 2009 |
Questionnaire owner
Contact
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Emily Banks (Professor)
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Sax Institute
Sydney Phone: 1300 45 11 45 Email: 45andup@saxinstitute.org.au |
Utilization conditions
The questionnaire is the intellectual property of the Sax Institute. Any party wishing to use the questionnaire must first seek permission from the Sax Institute.
Information on validity
The original questionnaire was refined in subsequent versions. Most participants (>85%) completed the final refined version. The refinements are not substantive changes and generally validity is unaffected. There are a small number of variables where changes to the question have affected the data. These are fully documented with processing algorithms developed to harmonise differences from changes to the questionnaire. Both documentation and data processing syntax are available to researchers.
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Legend
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Respondent
Administration environment
Administration mode
Administration format
Administration language
Available Format
NOTICE: HTML document format may differ slightly from the actual questionnaire. Please refer to the original PDF document for exact reproduction.
| Name | 45 and Up Study Baseline Questionnaire for Women |
|---|---|
| Number of Question Blocks | 45 |